ArticleRadiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology2011
Soy isoflavones radiosensitize lung cancer while mitigating normal tissue injury.
Article in Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 39 citations in OpenAlex.
- Consumption of soy isoflavone enriched bread in men with prostate cancer is associated with reduced proinflammatory cytokines and immunosuppressive cells.Cancer prevention research (Philadelphia, Pa.) · 2015Trial
- Soy-isoflavone to remedy induced or post-gamma-irradiation periodontitis in rat model.BMC oral health · 2026Article
- Radiomitigators: Breakthroughs in Post-Radiation Recovery.Antioxidants (Basel, Switzerland) · 2026Review
- Genistein Implications in Radiotherapy: Kill Two Birds with One Stone.Molecules (Basel, Switzerland) · 2025Review
- The use of Isoflavones as Lung Cancer Chemoprevention Agents and their Implications in Treatment through Radio Sensitization.Current medicinal chemistry · 2025Review
- Food Polyphenols in Radiation-Related Diseases: The Roles and Possible Mechanisms.Current nutrition reports · 2024Review
- Exploring Natural Products as Radioprotective Agents for Cancer Therapy: Mechanisms, Challenges, and Opportunities.Cancers · 2023Review
- Polyphenols as Potential Protectors against Radiation-Induced Adverse Effects in Patients with Thoracic Cancer.Cancers · 2023Review
- Study logistics that can impact medical countermeasure efficacy testing in mouse models of radiation injury.International journal of radiation biology · 2021Article
- Protecting HaCaT cells from ionizing radiation using persimmon tannin-Pharmaceutical biology · 2020Article
- Phytoestrogen genistein hinders ovarian oxidative damage and apoptotic cell death-induced by ionizing radiation: co-operative role of ER-β, TGF-β, and FOXL-2.Scientific reports · 2020Article
- Expanding the therapeutic index of radiation therapy by normal tissue protection.The British journal of radiology · 2019Review
- Radiation injury to cardiac arteries and myocardium is reduced by soy isoflavones.Journal of radiation oncology · 2017Article
- Innate Immune Pathways Associated with Lung Radioprotection by Soy Isoflavones.Frontiers in oncology · 2017Article
- Inhibition on Numb/Notch signal pathway enhances radiosensitivity of lung cancer cell line H358.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Soy Isoflavones Promote Radioprotection of Normal Lung Tissue by Inhibition of Radiation-Induced Activation of Macrophages and Neutrophils.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2015Article
- The ameliorative effect of silibinin against radiation-induced lung injury: protection of normal tissue without decreasing therapeutic efficacy in lung cancer.BMC pulmonary medicine · 2015Article
- Radiation-Induced Esophagitis is Mitigated by Soy Isoflavones.Frontiers in oncology · 2015Article
- Axitinib Improves Radiotherapy in Murine Xenograft Lung Tumors.Translational oncology · 2014Article
- Radioprotection of lung tissue by soy isoflavones.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2013Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundWe have demonstrated that soy isoflavones radiosensitize cancer cells. Prostate cancer patients receiving radiotherapy (RT) and soy tablets had reduced radiation toxicity to surrounding organs. We have now investigated the combination of soy with RT in lung cancer (NSCLC), for which RT is limited by radiation-induced pneumonitis.
methodsHuman A549 NSCLC cells were injected i.v. in nude mice to generate lung tumor nodules. Lung tumor-bearing mice were treated with left lung RT at 12 Gy and with oral soy treatments at 1mg/day for 30 days. Lung tissues were processed for histology.
resultsCompared to lung tumor nodules treated with soy isoflavones or radiation, lung tissues from mice treated with both modalities showed that soy isoflavones augmented radiation-induced destruction of A549 lung tumor nodules leading to small residual tumor nodules containing degenerating tumor cells with large vacuoles. Soy isoflavones decreased the hemorrhages, inflammation and fibrosis caused by radiation in lung tissue, suggesting protection of normal lung tissue.
conclusionsSoy isoflavones augment destruction of A549 lung tumor nodules by radiation, and also mitigate vascular damage, inflammation and fibrosis caused by radiation injury to normal lung tissue. Soy could be used as a non-toxic complementary approach to improve RT in NSCLC.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.