ArticleJournal of vascular and interventional radiology : JVIR2012
Dodecafluoropentane emulsion decreases infarct volume in a rabbit ischemic stroke model.
Article in Journal of vascular and interventional radiology : JVIR, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
20 citing papers in PubMed, 37 citations in OpenAlex.
- Therapeutic delivery of oxygen using artificial oxygen carriers demonstrates the possibility of treating a wide range of diseases.Journal of nanobiotechnology · 2025Review
- The impact of intravenous dodecafluoropentane on a murine model of acute lung injury.Intensive care medicine experimental · 2023Article
- Oxygen carriers affect kidney immunogenicity duringFrontiers in transplantation · 2023Article
- Perfluorocarbon-based oxygen carriers: from physics to physiology.Pflugers Archiv : European journal of physiology · 2021Review
- Development and Testing of Thrombolytics in Stroke.Journal of stroke · 2021Review
- Article
- Treatment of Swine Closed Head Injury with Perfluorocarbon NVX-428.Medical sciences (Basel, Switzerland) · 2020Article
- Imaging assessment of cardioprotection mediated by a dodecafluoropentane oxygen-carrier administered during myocardial infarction.Nuclear medicine and biology · 2019Article
- Protecting the ischaemic penumbra as an adjunct to thrombectomy for acute stroke.Nature reviews. Neurology · 2018Review
- Efficacy of the perfluorocarbon dodecafluoropentane as an adjunct to pre-hospital resuscitation.PloS one · 2018Article
- Dodecafluoropentane Improves Neurological Function Following Anterior Ischemic Stroke.Molecular neurobiology · 2017Article
- Tissue Concentration of Dodecafluoropentane (DDFP) Following Repeated IV Administration in the New Zealand White Rabbit.The AAPS journal · 2017Article
- Scavenging dissolved oxygen via acoustic droplet vaporization.Ultrasonics sonochemistry · 2016Article
- Dodecafluoropentane Emulsion Extends Window for tPA Therapy in a Rabbit Stroke Model.Molecular neurobiology · 2015Article
- Dodecafluoropentane emulsion elicits cardiac protection against myocardial infarction through an ATP-Sensitive K+ channel dependent mechanism.Cardiovascular drugs and therapy · 2014Article
- Dodecafluoropentane Emulsion (DDFPe) Decreases Stroke Size and Improves Neurological Scores in a Permanent Occlusion Rat Stroke Model.The open neurology journal · 2014Article
- Progress in dodecafluoropentane emulsion as a neuroprotective agent in a rabbit stroke model.Molecular neurobiology · 2013Article
- Three variations in rabbit angiographic stroke models.Journal of neuroscience methods · 2013Article
- Neurological assessment scores in rabbit embolic stroke models.The open neurology journal · 2013Article
- Development of Ultrasound Microbubbles and Phase Shift Microbubbles in Theranostics.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnologyReview
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
purposeTo assess the efficacy of dodecafluoropentane emulsion (DDFPe), a nanodroplet emulsion with significant oxygen transport potential, in decreasing infarct volume in an insoluble-emboli rabbit stroke model. MATERIALS AND
methodsNew Zealand White rabbits (N = 64; weight, 5.1 ± 0.50 kg) underwent angiography and received embolic spheres in occluded internal carotid artery branches. Rabbits were randomly assigned to groups in 4-hour and 7-hour studies. Four-hour groups included control (n = 7, embolized without treatment) and DDFPe treatment 30 minutes before stroke (n = 7), at stroke onset (n = 8), and 30 minutes (n = 5), 1 hour (n = 7), 2 hours (n = 5), or 3 hours after stroke (n = 6). Seven-hour groups included control (n = 6) and DDFPe at 1 hour (n = 8) and 6 hours after stroke (n = 5). DDFPe dose was a 2% weight/volume intravenous injection (0.6 mL/kg) repeated every 90 minutes as time allowed. After euthanasia, infarct volume was determined by vital stains on brain sections.
resultsAt 4 hours, median infarct volume decreased for all DDFPe treatment times (pretreatment, 0.30% [P = .004]; onset, 0.20% [P = .004]; 30 min, 0.35% [P = .009]; 1 h, 0.30% [P = .01]; 2 h, 0.40% [P = .009]; and 3 h, 0.25% [P = .003]) compared with controls (3.20%). At 7 hours, median infarct volume decreased with treatment at 1 hour (0.25%; P = .007) but not at 6 hours (1.4%; P = .49) compared with controls (2.2%).
conclusionsIntravenous DDFPe in an animal model decreases infarct volumes and protects brain tissue from ischemia, justifying further investigation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.