ArticleFood and chemical toxicology : an international journal published for the British Industrial Biological Research Association2012
Effect on pro-inflammatory and antioxidant genes and bioavailable distribution of whole turmeric vs curcumin: Similar root but different effects.
Article in Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
14 citing papers in PubMed, 63 citations in OpenAlex.
- Protective Effects of Curcumin against Alcoholic Fatty Liver.Current medicinal chemistry · 2025Review
- Curcumin Supplementation Ameliorates Bile Cholesterol Supersaturation in Hamsters by Modulating Gut Microbiota and Cholesterol Absorption.Nutrients · 2022Article
- Curcumin modulates gut microbiota and improves renal function in rats with uric acid nephropathy.Renal failure · 2021Article
- The Effects of Medicinal Plants and Bioactive Natural Compounds on Homocysteine.Molecules (Basel, Switzerland) · 2021Review
- Medicinal Plants and Phytochemicals Regulating Insulin Resistance and Glucose Homeostasis in Type 2 Diabetic Patients: A Clinical Review.Advances in experimental medicine and biology · 2021Review
- The beneficial effects of nutraceuticals and natural products on small dense LDL levels, LDL particle number and LDL particle size: a clinical review.Lipids in health and disease · 2020Review
- Prebiotic Potential of Culinary Spices Used to Support Digestion and Bioabsorption.Evidence-based complementary and alternative medicine : eCAM · 2019Article
- Molecular mechanisms of curcumin and its semisynthetic analogues in prostate cancer prevention and treatment.Life sciences · 2016Review
- Chili Peppers, Curcumins, and Prebiotics in Gastrointestinal Health and Disease.Current gastroenterology reports · 2016Review
- Hepatic protection and anticancer activity of curcuma: a potential chemopreventive strategy against hepatocellular carcinoma.International journal of oncology · 2014Article
- Liposomal formulation of turmerone-rich hexane fractions from Curcuma longa enhances their antileishmanial activity.BioMed research international · 2014Article
- Curcuma Contra Cancer? Curcumin and Hodgkin's Lymphoma.Cancer growth and metastasis · 2013Review
- Maturation and upregulation of functions of murine dendritic cells (DCs) under the influence of purified aromatic-turmerone (AR).Human vaccines & immunotherapeutics · 2012Article
- Effects of Turmeric and Curcumin Dietary Supplementation on Human Gut Microbiota: A Double-Blind, Randomized, Placebo-Controlled Pilot Study.Journal of evidence-based integrative medicineArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Curcuma longa is a perennial member of the Zingiberaceae family, and cultivated mainly in India, and Southeast Asia. The hypothesis for this study is that turmeric will have distinctive effects from curcumin due to the presence of other bioactive compounds. Thirty Eight-week old Sprague-Dawley rats were separated into three oral feeding groups. Group 1, standard rat chow, Control diet - AIN 93M, group 2 - Curcumin - 700ppm or 0.7g/kg diet, and group 3 - Turmeric - 14,000ppm or 14g/kg diet for a total of 3weeks. One group of rats were feed all three diets only and another group underwent esophagoduodenal anastomosis to evaluate the effects of bioavailability. Curcumin diet did not increase the transcription of mRNA of TNF-alpha, IL-6, iNOS, and COX-2. The average fold change in the mRNAs level was not significant. Whereas turmeric diet increases the levels of IL-6 (1.9-fold, p=0.05), iNOS (4.39-fold, p=0.02), IL-8 (3.11-fold, p=0.04), and COX-2 (2.02-fold, p=0.05), suggesting that turmeric either was more bioavailable or had more affect on pro-inflammatory genes compare to curcumin diet. We have demonstrated the molecular effects of curcumin and turmeric in the role as an anti-inflammatory therapy. However, significant bioavailable differences do occur and must be considered in further chemopreventative investigative trials the setting of reflux esophagitis, Barrett's esophagus, and other upper gastrointestinal cancers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.