ArticleJournal of inflammation (London, England)2011
Cytokine & chemokine response in the lungs, pleural fluid and serum in thoracic surgery using one-lung ventilation.
Article in Journal of inflammation (London, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- The impact of different inspired oxygen concentrations combined with nebulized prostaglandin E1 on oxygenation in patients undergoing one-lung ventilation: a randomized controlled trial.BMC anesthesiology · 2025Trial
- Trial
- Systemic, Pleural, and Alveolar Cytokine Responses After Video-Assisted Thoracoscopic Versus Open Lobectomy for Non-Small Cell Lung Cancer: A Prospective Observational Study.Journal of clinical medicine · 2026Article
- Lidocaine as a promising adjunct to reduce complications after lung resection.Journal of thoracic disease · 2026Article
- Intraoperative Ventilatory Strategies in Patients Undergoing Video-Assisted Thoracic Surgery: A Narrative Review.Advances in therapy · 2025Review
- PD-1 Blockade Mitigates Surgery-Induced Immunosuppression and Increases the Efficacy of Photodynamic Therapy for Pleural Mesothelioma.Cancer research communications · 2025Article
- Acute inflammatory profile of patients submitted to pulmonary resection.Acta cirurgica brasileira · 2025Article
- Identifying biomarkers of ventilator induced lung injury during one-lung ventilation surgery: a scoping review.Journal of thoracic disease · 2022Article
- Anesthetic (r)evolution from the conventional concept to the minimally invasive techniques in thoracic surgery-narrative review.Journal of thoracic disease · 2022Review
- Perioperative Systemic Inflammation in Lung Cancer Surgery.Frontiers in surgery · 2022Review
- Pathophysiological Advantages of Spontaneous Ventilation.Frontiers in surgery · 2022Review
- Association of an expanded inflammatory mediators response with clinical and laboratory data in the postoperative period of pulmonary resection: a prospective clinical study.Revista do Colegio Brasileiro de Cirurgioes · 2021Article
- Effect of Dexmedetomidine on Postoperative Lung Injury during One-Lung Ventilation in Thoracoscopic Surgery.BioMed research international · 2020Article
- Short-term one-lung ventilation does not influence local inflammatory cytokine response after lung resection.Journal of thoracic disease · 2018Article
- Effects of volume-controlled ventilationJournal of thoracic disease · 2018Article
- Lung cancer prediction using neural network ensemble with histogram of oriented gradient genomic features.TheScientificWorldJournal · 2015Article
- Serial characterisation of monocyte and neutrophil function after lung resection.BMJ open respiratory research · 2014Article
- [Predictive value of plasma cytokines for acute kidney injury following lung resection surgery: prospective observational study].Brazilian journal of anesthesiology (Elsevier)Observational
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThoracic surgery mandates usually a one-lung ventilation (OLV) strategy with the collapse of the operated lung and ventilation of the non-operated lung. These procedures trigger a substantial inflammatory response. The aim of this study was to analyze the cytokine and chemokine reaction in both lungs, pleural space and blood in patients undergoing lung resection with OLV with special interest in the chemokine growth-regulated peptide alpha (GROα) which is the human equivalent to the rat cytokine-induced neutrophil chemoattractant-1 (CINC-1).
methodsBroncho-alveolar lavage (BAL) fluid of both the collapsed, operated and the ventilated, non-operated lung, respectively, pleural space drainage fluid and blood was collected and the concentrations of interleukin (IL)-6, IL-1RA and GROα were determined with enzyme-linked immunosorbent assays in 15 patients.
resultsSubstantial inter-individual differences in the BAL fluid between patients in cytokine and chemokine levels occurred. In the pleural fluid and the blood these inter-individual differences were less pronounced. Both sides of the lung were affected and showed a significant increase in IL-6 and IL-1RA concentrations over time but not in GROα concentrations. Except for IL-6, which increased more in the collapsed, operated lung, no difference between the collapsed, operated and the ventilated, non-operated lung occurred. In the blood, IL-6 and IL-1RA increased early, already at the end of surgery. GROα was not detectable. In the pleural fluid, both cytokine and chemokine concentrations increased by day one. The increase was significantly higher in the pleural fluid compared to the blood.
conclusionThe inflammatory response of cytokines affects both the collapsed, operated and the ventilated, non-operated lungs. The difference in extent of response underlines the complexity of the inflammatory processes during OLV. In contrast to the cytokines, the chemokine GROα concentrations did not react in the BAL fluid or in the blood. This indicates that GROα might not be useful as marker for the inflammatory reaction in complex surgical procedures.
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