ArticleStructure (London, England : 1993)2011
Classification of a Haemophilus influenzae ABC transporter HI1470/71 through its cognate molybdate periplasmic binding protein, MolA.
Article in Structure (London, England : 1993), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed, 36 citations in OpenAlex.
- The Evolution of ABC Importers.Journal of molecular biology · 2025Review
- Structurally diverse C-terminal accessory domains in type I ABC importers reveal distinct regulatory mechanisms.Structure (London, England : 1993) · 2025Review
- Molybdate uptake interplay with ROS tolerance modulates bacterial pathogenesis.Science advances · 2025Article
- Article
- Structural and functional insights into iron acquisition from lactoferrin and transferrin in Gram-negative bacterial pathogens.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2023Article
- The molybdate-binding protein ModA is required forFrontiers in microbiology · 2023Article
- The Impact of Chromate onFrontiers in microbiology · 2022Article
- Structural characterization of two solute-binding proteins forJournal of structural biology: X · 2021Article
- Molybdenum Enzymes and How They Support Virulence in Pathogenic Bacteria.Frontiers in microbiology · 2020Review
- Determination of Ligand Profiles forInternational journal of molecular sciences · 2019Article
- pH- and Temperature-Dependent Peptide Binding to theACS omega · 2019Article
- In vitro reassembly of the ribose ATP-binding cassette transporter reveals a distinct set of transport complexes.The Journal of biological chemistry · 2015Article
- Acquisition and role of molybdate in Pseudomonas aeruginosa.Applied and environmental microbiology · 2014Article
- Small substrate transport and mechanism of a molybdate ATP binding cassette transporter in a lipid environment.The Journal of biological chemistry · 2014Article
- Structural diversity of ABC transporters.The Journal of general physiology · 2014Review
- Comparative genomic analysis reveals distinct genotypic features of the emerging pathogen Haemophilus influenzae type f.BMC genomics · 2014Article
- Molecular details of ligand selectivity determinants in a promiscuous β-glucan periplasmic binding protein.BMC structural biology · 2013Article
- EPR spectroscopy of MolB2C2-a reveals mechanism of transport for a bacterial type II molybdate importer.The Journal of biological chemistry · 2013Article
- Two molybdate/tungstate ABC transporters that interact very differently with their substrate binding proteins.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- X-ray structure of the Yersinia pestis heme transporter HmuUV.Nature structural & molecular biology · 2012Article
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4 authors at 3 institutions in 1 country.
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Abstract
molA (HI1472) from H. influenzae encodes a periplasmic binding protein (PBP) that delivers substrate to the ABC transporter MolB(2)C(2) (formerly HI1470/71). The structures of MolA with molybdate and tungstate in the binding pocket were solved to 1.6 and 1.7 Å resolution, respectively. The MolA-binding protein binds molybdate and tungstate, but not other oxyanions such as sulfate and phosphate, making it the first class III molybdate-binding protein structurally solved. The ∼100 μM binding affinity for tungstate and molybdate is significantly lower than observed for the class II ModA molybdate-binding proteins that have nanomolar to low micromolar affinity for molybdate. The presence of two molybdate loci in H. influenzae suggests multiple transport systems for one substrate, with molABC constituting a low-affinity molybdate locus.
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