ReviewCurrent opinion in pharmacology2012
Hyperalgesia by synaptic long-term potentiation (LTP): an update.
Review in Current opinion in pharmacology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06946290 (Intertransverse Process Block to Improve Quality of Recovery and Pain Management in Adult Cardiac Surgical Patients), which is not on this map. Cited by 86 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Intertransverse Process Block to Improve Quality of Recovery and Pain Management in Adult Cardiac Surgical Patients: a Prospective Double-Blinded Randomized Controlled Trial
Who cites it
86 citing papers in PubMed, 5 syntheses or guidelines pooled it, 186 citations in OpenAlex.
- Pooled it
- Human surrogate models of central sensitization: A critical review and practical guide.European journal of pain (London, England) · 2021Pooled it
- Perioperative intravenous ketamine for acute postoperative pain in adults.The Cochrane database of systematic reviews · 2018Pooled it
- Regional anaesthesia to prevent chronic pain after surgery: a Cochrane systematic review and meta-analysis.British journal of anaesthesia · 2013Pooled it
- Pooled it
- Comparison between ultrasound guided erector spinae plane block and paravertebral block on acute and chronic post mastectomy pain after modified radical mastectomy: randomized controlled trial.BMC anesthesiology · 2024Trial
- Effects of Remifentanil Gradual Withdrawal Combined with Postoperative Infusion on Postoperative Hyperalgesia in Patients Undergoing Laparoscopic hysterectomy: A Factorial Design, Double-Blind, Randomized Controlled Trial.Drug design, development and therapy · 2024Trial
- Gradual withdrawal of remifentanil delays initial post-operative analgesic demand after thyroid surgery; double-blinded, randomized controlled trial.BMC anesthesiology · 2019Trial
- [Neuromodulation using matrix stimulation : A treatment for acute pain?]Schmerz (Berlin, Germany) · 2017Trial
- Trial
- Glial cells in neuropathic pain.Physiological reviews · 2026Review
- Targeting Central Sensitization for Pain Management in Knee Osteoarthritis: A Narrative Review of Mechanisms and Clinical Applications of Neuromodulation.Journal of pain research · 2026Review
- Unique RNA Gene Expression Profile Is Seen in Chronic Non-Specific Low Back Pain.International journal of molecular sciences · 2025Article
- Electrophysiological Methods to Assess Peripheral Pain Block in an Anesthetized Rat.Journal of visualized experiments : JoVE · 2025Article
- The upside of epilepsy: Theories of an evolutionary paradox.Epilepsia open · 2025Review
- mGluR5-mediated astrocytes hyperactivity in the anterior cingulate cortex contributes to neuropathic pain in male mice.Communications biology · 2025Article
- Article
- The Trigeminal Sensory System and Orofacial Pain.International journal of molecular sciences · 2024Review
- Brain-Derived Neurotrophic Factor, Nociception, and Pain.Biomolecules · 2024Review
- Review
26 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Long-term potentiation of synaptic strength (LTP) in nociceptive pathways shares principle features with hyperalgesia including induction protocols, pharmacological profile, neuronal and glial cell types involved and means for prevention. LTP at synapses of nociceptive nerve fibres constitutes a contemporary cellular model for pain amplification following trauma, inflammation, nerve injury or withdrawal from opioids. It provides a novel target for pain therapy. This review summarizes recent progress which has been made in unravelling the properties and functions of LTP in the nociceptive system and in identifying means for its prevention and reversal.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.