ArticleBMC complementary and alternative medicine2011
Inhibitory effect of aqueous Dandelion extract on HIV-1 replication and reverse transcriptase activity.
Article in BMC complementary and alternative medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Botany, Traditional Use, Phytochemistry, Pharmacology and Quality Control ofPharmaceuticals (Basel, Switzerland) · 2024Review
- Effect of Chinese herbal medicine therapy on risks of all-cause mortality, infections, parasites, and circulatory-related mortality in HIV/AIDS patients with neurological diseases.Frontiers in pharmacology · 2023Article
- Antiviral activity of dandelion aqueous extract against pseudorabies virus bothFrontiers in veterinary science · 2022Article
- A Review on Measures to Rejuvenate Immune System: Natural Mode of Protection Against Coronavirus Infection.Frontiers in immunology · 2022Review
- Plants-Derived Biomolecules as Potent Antiviral Phytomedicines: New Insights on Ethnobotanical Evidences against Coronaviruses.Plants (Basel, Switzerland) · 2020Review
- In vitro inhibition effects of hepatitis B virus by dandelion and taraxasterol.Infectious agents and cancer · 2020Article
- MR-10 Enhances Men's Health by Improving Endogenous Male Sex Hormone Generation.Journal of medicinal food · 2018Article
- Article
- Taraxacum officinale and Urtica dioica extracts inhibit dengue virus serotype 2 replication in vitro.BMC complementary and alternative medicine · 2018Article
- Protective effects of quercetin and taraxasterol against HExperimental and therapeutic medicine · 2015Article
- Medicinal herb extracts ameliorate impaired growth performance and intestinal lesion of newborn piglets challenged with the virulent porcine epidemic diarrhea virus.Journal of animal science and technology · 2015Article
- Extracts of medicinal herbYao wu shi pin fen xi = Journal of food and drug analysis · 2013Article
- Characterization of antiviral activity of benzamide derivative AH0109 against HIV-1 infection.Antimicrobial agents and chemotherapy · 2013Article
- Extract of Scutellaria baicalensis inhibits dengue virus replication.BMC complementary and alternative medicine · 2013Article
- Novel antiviral activity of baicalein against dengue virus.BMC complementary and alternative medicine · 2012Article
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4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundAcquired immunodeficiency syndrome (AIDS), which is caused by the human immunodeficiency virus (HIV), is an immunosuppressive disease that results in life-threatening opportunistic infections. The general problems in current therapy include the constant emergence of drug-resistant HIV strains, adverse side effects and the unavailability of treatments in developing countries. Natural products from herbs with the abilities to inhibit HIV-1 life cycle at different stages, have served as excellent sources of new anti-HIV-1 drugs. In this study, we aimed to investigate the anti-HIV-1 activity of aqueous dandelion extract.
methodsThe pseudotyped HIV-1 virus has been utilized to explore the anti-HIV-1 activity of dandelion, the level of HIV-1 replication was assessed by the percentage of GFP-positive cells. The inhibitory effect of the dandelion extract on reverse transcriptase activity was assessed by the reverse transcriptase assay kit.
resultsCompared to control values obtained from cells infected without treatment, the level of HIV-1 replication and reverse transcriptase activity were decreased in a dose-dependent manner. The data suggest that dandelion extract has a potent inhibitory activity against HIV-1 replication and reverse transcriptase activity. The identification of HIV-1 antiviral compounds from Taraxacum officinale should be pursued.
conclusionsThe dandelion extract showed strong activity against HIV-1 RT and inhibited both the HIV-1 vector and the hybrid-MoMuLV/MoMuSV retrovirus replication. These findings provide additional support for the potential therapeutic efficacy of Taraxacum officinale. Extracts from this plant may be regarded as another starting point for the development of an antiretroviral therapy with fewer side effects.
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