ArticleStem cells (Dayton, Ohio)2012
Barx2 is expressed in satellite cells and is required for normal muscle growth and regeneration.
Article in Stem cells (Dayton, Ohio), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 41 citations in OpenAlex.
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- Pancancer analysis of oncogenic BARX2 identifying its prognostic value and immunological function in liver hepatocellular carcinoma.Scientific reports · 2023Article
- Effect of Zbed6 Single-Allele Knockout on the Growth and Development of Skeletal Muscle in Mice.Biology · 2023Article
- IL6 supports long-term expansion of hepatocytes in vitro.Nature communications · 2022Article
- Genomic insights into the conservation and population genetics of two Chinese native goat breeds.Journal of animal science · 2022Article
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- Pannexin 1 Regulates Skeletal Muscle Regeneration by Promoting Bleb-Based Myoblast Migration and Fusion Through a Novel Lipid Based Signaling Mechanism.Frontiers in cell and developmental biology · 2021Article
- Skeletal muscle as an experimental model of choice to study tissue aging and rejuvenation.Skeletal muscle · 2020Review
- A Promising Future for Stem-Cell-Based Therapies in Muscular Dystrophies-In Vitro and In Vivo Treatments to Boost Cellular Engraftment.International journal of molecular sciences · 2019Review
- Effects of Autologous Fat and ASCs on Swine Hypertrophic Burn Scars: A Multimodal Quantitative Analysis.Plastic and reconstructive surgery. Global open · 2017Article
- Genome Editing and Muscle Stem Cells as a Therapeutic Tool for Muscular Dystrophies.Current stem cell reports · 2017Review
- CLIP-GENE: a web service of the condition specific context-laid integrative analysis for gene prioritization in mouse TF knockout experiments.Biology direct · 2016Article
- Barx2 and Pax7 Regulate Axin2 Expression in Myoblasts by Interaction with β-Catenin and Chromatin Remodelling.Stem cells (Dayton, Ohio) · 2016Article
- Muscle Satellite Cells: Exploring the Basic Biology to Rule Them.Stem cells international · 2016Review
- De Novo ring chromosome 11 and non-reciprocal translocation of 11p15.3-pter to 21qter in a patient with congenital heart disease.Molecular cytogenetics · 2015Article
- Satellite cells: regenerative mechanisms and applicability in muscular dystrophy.Stem cells international · 2015Review
- A genome-wide scan for selection signatures in Yorkshire and Landrace pigs based on sequencing data.Animal genetics · 2014Article
- Localization of sarcomeric proteins during myofibril assembly in cultured mouse primary skeletal myotubes.Anatomical record (Hoboken, N.J. : 2007) · 2014Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
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Abstract
Muscle growth and regeneration are regulated through a series of spatiotemporally dependent signaling and transcriptional cascades. Although the transcriptional program controlling myogenesis has been extensively investigated, the full repertoire of transcriptional regulators involved in this process is far from defined. Various homeodomain transcription factors have been shown to play important roles in both muscle development and muscle satellite cell-dependent repair. Here, we show that the homeodomain factor Barx2 is a new marker for embryonic and adult myoblasts and is required for normal postnatal muscle growth and repair. Barx2 is coexpressed with Pax7, which is the canonical marker of satellite cells, and is upregulated in satellite cells after muscle injury. Mice lacking the Barx2 gene show reduced postnatal muscle growth, muscle atrophy, and defective muscle repair. Moreover, loss of Barx2 delays the expression of genes that control proliferation and differentiation in regenerating muscle. Consistent with the in vivo observations, satellite cell-derived myoblasts cultured from Barx2(-/-) mice show decreased proliferation and ability to differentiate relative to those from wild-type or Barx2(+/-) mice. Barx2(-/-) myoblasts show reduced expression of the differentiation-associated factor myogenin as well as cell adhesion and matrix molecules. Finally, we find that mice lacking both Barx2 and dystrophin gene expression have severe early onset myopathy. Together, these data indicate that Barx2 is an important regulator of muscle growth and repair that acts via the control of satellite cell proliferation and differentiation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.