ArticleJournal of molecular evolution2011
Unassigned codons, nonsense suppression, and anticodon modifications in the evolution of the genetic code.
Article in Journal of molecular evolution, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 22 citations in OpenAlex.
- Overview of tRNA Modifications in Chloroplasts.Microorganisms · 2022Article
- Crick Wobble and Superwobble in Standard Genetic Code Evolution.Journal of molecular evolution · 2021Article
- Article
- A Non-neutral Origin for Error Minimization in the Origin of the Genetic Code.Journal of molecular evolution · 2018Article
- Celebrating wobble decoding: Half a century and still much is new.RNA biology · 2018Review
- Future of the Genetic Code.Life (Basel, Switzerland) · 2017Review
- An integrated, structure- and energy-based view of the genetic code.Nucleic acids research · 2016Review
- Anticodon Modifications in the tRNA Set of LUCA and the Fundamental Regularity in the Standard Genetic Code.PloS one · 2016Article
- On the Origin of Sequence.Life (Basel, Switzerland) · 2015Review
- Non-Standard Genetic Codes Define New Concepts for Protein Engineering.Life (Basel, Switzerland) · 2015Review
- Pathways of Genetic Code Evolution in Ancient and Modern Organisms.Journal of molecular evolution · 2015Review
- Evolution of the genetic code by incorporation of amino acids that improved or changed protein function.Journal of molecular evolution · 2013Article
- A realistic model under which the genetic code is optimal.Journal of molecular evolution · 2013Article
- Decoding in Candidatus Riesia pediculicola, close to a minimal tRNA modification set?Trends in cell & molecular biology · 2012Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The origin of the genetic code is a central open problem regarding the early evolution of life. Here, we consider two undeveloped but important aspects of possible scenarios for the evolutionary pathway of the translation machinery: the role of unassigned codons in early stages of the code and the incorporation of tRNA anticodon modifications. As the first codons started to encode amino acids, the translation machinery likely was faced with a large number of unassigned codons. Current molecular scenarios for the evolution of the code usually assume the very rapid assignment of all codons before all 20 amino acids became encoded. We show that the phenomenon of nonsense suppression as observed in current organisms allows for a scenario in which many unassigned codons persisted throughout most of the evolutionary development of the code. In addition, we demonstrate that incorporation of anticodon modifications at a late stage is feasible. The wobble rules allow a set of 20 tRNAs fully lacking anticodon modifications to encode all 20 canonical amino acids. These observations have implications for the biochemical plausibility of early stages in the evolution of the genetic code predating tRNA anticodon modifications and allow for effective translation by a relatively small and simple early tRNA set.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.