ArticleNeurochemical research2012
FoxO3a changes in pyramidal neurons and expresses in non-pyramidal neurons and astrocytes in the gerbil hippocampal CA1 region after transient cerebral ischemia.
Article in Neurochemical research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Structural and Pharmacological Network Analysis of miRNAs Involved in Acute Ischemic Stroke: A Systematic Review.International journal of molecular sciences · 2022Pooled it
- Upregulation of Foxo3a protects neurons against hypoxia-ischaemia injury.Archives of medical science : AMS · 2026Article
- Regulation of mitochondrial function by FOXOs in ischemic stroke and Alzheimer's disease.Organelle (Tucson, Ariz.) · 2024Article
- Exploring the Regulatory Mechanism ofFrontiers in pharmacology · 2021Article
- Licoricidin improves neurological dysfunction after traumatic brain injury in mice via regulating FoxO3/Wnt/β-catenin pathway.Journal of natural medicines · 2020Article
- Article
- Autophagy in Traumatic Brain Injury: A New Target for Therapeutic Intervention.Frontiers in molecular neuroscience · 2018Review
- Neuroprotection of Chrysanthemum indicum Linne against cerebral ischemia/reperfusion injury by anti-inflammatory effect in gerbils.Neural regeneration research · 2016Article
- Regeneration in the nervous system with erythropoietin.Frontiers in bioscience (Landmark edition) · 2016Review
- Erythropoietin and diabetes mellitus.World journal of diabetes · 2015Review
- FoxO proteins in the nervous system.Analytical cellular pathology (Amsterdam) · 2015Review
- Time-course changes in immunoreactivities of glucokinase and glucokinase regulatory protein in the gerbil hippocampus following transient cerebral ischemia.Neurochemical research · 2013Article
- Shedding new light on neurodegenerative diseases through the mammalian target of rapamycin.Progress in neurobiology · 2012Review
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Authors and funding
10 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The forkhead box O (FoxO) proteins regulate processes ranging from cell longevity to cell apoptosis and function as transcription factors. FoxO3a is expressed throughout the brain including the hippocampus. In the present study, we investigated the changes in FoxO3a immunoreactivity and its protein levels in the gerbil hippocampal CA1 region after 5 min of transient global cerebral ischemia. FoxO3a immunoreactivity and protein levels in the ischemic CA1 region, which is very vulnerable to ischemic damage, were slightly decreased from 3 h after ischemia-reperfusion (I-R) and maintained until 12 h after I-R. One and 2 days after I-R, FoxO3a immunoreactivity and protein levels were similar to those in the sham-operated group. At 3 days after I-R, FoxO3a immunoreactivity and protein levels were markedly increased in the CA1 region. FoxO3a immunoreactivity was hardly detected in pyramidal neurons from 5 days after I-R; however, at 5 days after I-R, FoxO3a immunoreactivity was detected in astrocytes and GABAergic interneurons of the ischemic CA1 region. These results indicate that both FoxO3a immunoreactivity and protein levels are distinctively altered in the ischemic CA1 region after transient cerebral ischemia, and that the changes in FoxO3a expression may be related to the ischemia-induced delayed neuronal death.
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