ArticleMammalian genome : official journal of the International Mammalian Genome Society2012
Annotation of the domestic dog genome sequence: finding the missing genes.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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Who cites it
8 citing papers in PubMed, 16 citations in OpenAlex.
- Expression of Behavioural Traits in Goldendoodles and Labradoodles.Animals : an open access journal from MDPI · 2019Article
- Variants in the interleukin-1 alpha and beta genes, and the risk for periodontal disease in dogs.Journal of genetics · 2015Article
- Article
- Dog and mouse: toward a balanced view of the mammalian olfactory system.Frontiers in neuroanatomy · 2014Article
- Analysis of the canine brain transcriptome with an emphasis on the hypothalamus and cerebral cortex.Mammalian genome : official journal of the International Mammalian Genome Society · 2013Article
- Comparative RNA-Seq and microarray analysis of gene expression changes in B-cell lymphomas of Canis familiaris.PloS one · 2013Article
- Franklin H. Epstein Lecture. Both ends of the leash--the human links to good dogs with bad genes.The New England journal of medicine · 2012Article
- Genome-wide mRNA sequencing of a single canine cerebellar cortical degeneration case leads to the identification of a disease associated SPTBN2 mutation.BMC genetics · 2012Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There are over 350 genetically distinct breeds of domestic dog that present considerable variation in morphology, physiology, and disease susceptibility. The genome sequence of the domestic dog was assembled and released in 2005, providing an estimated 20,000 protein-coding genes that are a great asset to the scientific community that uses the dog system as a genetic biomedical model and for comparative and evolutionary studies. Although the canine gene set had been predicted using a combination of ab initio methods, homology studies, motif analysis, and similarity-based programs, it still requires a deep annotation of noncoding genes, alternative splicing, pseudogenes, regulatory regions, and gain and loss events. Such analyses could benefit from new sequencing technologies (RNA-Seq) to better exploit the advantages of the canine genetic system in tracking disease genes. Here, we review the catalog of canine protein-coding genes and the search for missing genes, and we propose rationales for an accurate identification of noncoding genes though next-generation sequencing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.