ArticleBiomedical optics express2011
Measurement and correction of in vivo sample aberrations employing a nonlinear guide-star in two-photon excited fluorescence microscopy.
Article in Biomedical optics express, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
- Enhancing volumetric microscopy with blind computational correction of spatially variant aberrations using neural field representation.bioRxiv : the preprint server for biology · 2026Article
- Machine learning assisted wavefront sensor.Proceedings of SPIE--the International Society for Optical Engineering · 2026Article
- Compressive Fourier-Domain Intensity Coupling (C-FOCUS) enables near-millimeter deep imaging in the intact mouse brain in vivo.Research square · 2025Article
- Multiphoton Neurophotonics: Recent Advances in Imaging and Manipulating Neuronal Circuits.ACS photonics · 2025Review
- Review
- Adaptive optics in an oblique plane microscope.Biomedical optics express · 2024Article
- Adaptive Optics in an Oblique Plane Microscope.bioRxiv : the preprint server for biology · 2024Article
- Article
- Construction and use of an adaptive optics two-photon microscope with direct wavefront sensing.Nature protocols · 2023Review
- Adaptive optics for optical microscopy [Invited].Biomedical optics express · 2023Review
- Imaging mitochondria through bone in live mice using two-photon fluorescence microscopy with adaptive optics.Frontiers in neuroimaging · 2023Article
- Active image optimization for lattice light sheet microscopy in thick samples.Biomedical optics express · 2022Article
- Recent advances in optical imaging through deep tissue: imaging probes and techniques.Biomaterials research · 2022Review
- Multi-segmented feature coupling for jointly reconstructing initial pressure and speed of sound in photoacoustic computed tomography.Journal of biomedical optics · 2022Article
- Neurophotonic tools for microscopic measurements and manipulation: status report.Neurophotonics · 2022Article
- Fast holographic scattering compensation for deep tissue biological imaging.Nature communications · 2021Article
- Subcellular three-dimensional imaging deep through multicellular thick samples by structured illumination microscopy and adaptive optics.Nature communications · 2021Article
- Article
- Adaptive photoacoustic computed tomography.Photoacoustics · 2021Article
- Laser scanning reflection-matrix microscopy for aberration-free imaging through intact mouse skull.Nature communications · 2020Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We demonstrate that sample induced aberrations can be measured in a nonlinear microscope. This uses the fact that two-photon excited fluorescence naturally produces a localized point source inside the sample: the nonlinear guide-star (NL-GS). The wavefront emitted from the NL-GS can then be recorded using a Shack-Hartmann sensor. Compensation of the recorded sample aberrations is performed by the deformable mirror in a single-step. This technique is applied to fixed and in vivo biological samples, showing, in some cases, more than one order of magnitude improvement in the total collected signal intensity.
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