Evidence map›Paper›PMID 22076264›Full record

ArticleBiomedical optics express2011

Imaging workflow and calibration for CT-guided time-domain fluorescence tomography.

Kenneth M Tichauer, Robert W Holt, Fadi El-Ghussein, Qun Zhu, Hamid Dehghani, Frederic Leblond, Brian W Pogue

Abstract read
In one paragraph

Article in Biomedical optics express, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
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  13. Information loss and reconstruction in diffuse fluorescence tomography.Journal of the Optical Society of America. A, Optics, image science, and vision · 2012
    Article
  14. Ex vivo fluorescence molecular tomography of the spine.International journal of biomedical imaging · 2012
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kenneth M Tichauer
Robert W Holt
Fadi El-Ghussein
Qun Zhu
Hamid Dehghani
Frederic Leblond
Brian W Pogue

Funding

Micro CT/NIR Molecular Imaging of CancerR01CA120368 · NCI · DARTMOUTH COLLEGE · PI POGUE, BRIAN WILLIAM · 2007 to 2011
$1.2M
X-ray/Fluorescence Molecular and Diffuse Optical Tomography of GliomaK25CA138578 · NCI · DARTMOUTH COLLEGE · PI LEBLOND, FREDERIC · 2009 to 2012
$722k
NCI NIH HHS K25 CA138578NCI NIH HHS R01 CA120368
6 · The paper itself

Abstract

In this study, several key optimization steps are outlined for a non-contact, time-correlated single photon counting small animal optical tomography system, using simultaneous collection of both fluorescence and transmittance data. The system is presented for time-domain image reconstruction in vivo, illustrating the sensitivity from single photon counting and the calibration steps needed to accurately process the data. In particular, laser time- and amplitude-referencing, detector and filter calibrations, and collection of a suitable instrument response function are all presented in the context of time-domain fluorescence tomography and a fully automated workflow is described. Preliminary phantom time-domain reconstructed images demonstrate the fidelity of the workflow for fluorescence tomography based on signal from multiple time gates.

Indexed as

(170.0110) Imaging systems(170.3010) Image reconstruction techniques(170.3660) Light propagation in tissues

Identifiers

PMID22076264
PMCPMC3207372

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.