Trial reportPsychopharmacology2012
Effects of dexamphetamine with and without alcohol on simulated driving.
Trial report in Psychopharmacology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 3 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Systematic reviews of the acute effects of amphetamine on working memory and other cognitive performances in healthy individuals, with a focus on the potential influence of personality traits.Human psychopharmacology · 2023Pooled it
- Alcohol consumption for simulated driving performance: A systematic review.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2017Pooled it
- Are there any potentially dangerous pharmacological effects of combining ADHD medication with alcohol and drugs of abuse? A systematic review of the literature.BMC psychiatry · 2015Pooled it
- Acute neurocognitive and subjective effects of oral methamphetamine with low doses of alcohol: A randomised controlled trial.Journal of psychopharmacology (Oxford, England) · 2023Trial
- Effects of three therapeutic doses of codeine/paracetamol on driving performance, a psychomotor vigilance test, and subjective feelings.Psychopharmacology · 2013Trial
- Is there a relationship between abuse of alcohol and illicit drugs seen in hair results?Drug testing and analysis · 2025Article
- The effect of listening to Iranian pop and classical music, on mental and physiological drowsiness.Sleep and biological rhythms · 2022Article
- A Hybrid Approach to Detect Driver Drowsiness Utilizing Physiological Signals to Improve System Performance and Wearability.Sensors (Basel, Switzerland) · 2017Article
- Effect of chronic opioid therapy on actual driving performance in non-cancer pain patients.Psychopharmacology · 2017Article
- Comparing treatment effects of oral THC on simulated and on-the-road driving performance: testing the validity of driving simulator drug research.Psychopharmacology · 2015Article
- Alcohol calibration of tests measuring skills related to car driving.Psychopharmacology · 2014Article
- Effects of alcohol on automated and controlled driving performances.Psychopharmacology · 2014Article
- Detecting driver drowsiness based on sensors: a review.Sensors (Basel, Switzerland) · 2012Review
- Effects of stimulant drugs on actual and simulated driving: perspectives from four experimental studies conducted as part of the DRUID research consortium.Psychopharmacology · 2012Article
Corrections and comments
- Commented on by
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleIn party circuits dexamphetamine is frequently used in combination with alcohol. It is hypothesized that co-administration of dexamphetamine to alcohol might reduce the sedative effects of alcohol, but may potentiate risk-taking behaviour.
objectivesThe study was aimed at assessing the effects of alcohol, dexamphetamine and the combination of both on simulated driving and cognitive performance.
methodEighteen subjects participated in a randomized, crossover, placebo-controlled study employing four conditions: 10 mg dexamphetamine, 0.8 g/kg alcohol, 10 mg dexamphetamine + 0.8 g/kg alcohol, and placebo. Fundamental driving skills and risk-taking behaviour were assessed in a driving simulator. Subjects also completed vigilance and divided attention tasks, and subjective ratings.
resultsMean BAC levels during simulated driving were between 0.91‰ and 0.64‰. Subjects using alcohol showed a significantly larger mean standard deviation of lateral position and shorter accepted gap time and distance. Use of alcohol or dexamphetamine + alcohol was associated with a higher frequency of red light running and collisions than the dexamphetamine or placebo conditions. Performance of vigilance and divided attention tasks was significantly impaired in the alcohol condition and, to a lesser degree, in the dexamphetamine + alcohol condition.
conclusionSingle doses of 0.8 g/kg alcohol increased risk-taking behaviours and impaired tracking, attention and reaction time during a 3-h period after drinking when BACs declined from 0.9 to 0.2 mg/ml. The stimulatory effects of co-administration of dexamphetamine 10 mg were not sufficient to overcome the impairing effects of alcohol on skills related to driving.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.