ArticleJournal of gastric cancer2010
Microsatellite instability is associated with the clinicopathologic features of gastric cancer in sporadic gastric cancer patients.
Article in Journal of gastric cancer, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 22 citations in OpenAlex.
- Clinico-pathologic characteristics of sub-epithelial tumor (SET) like gastric cancers.Scientific reports · 2026Article
- Microsatellite Status Affects Tumor Response and Survival in Patients Undergoing Neoadjuvant Chemotherapy for Clinical Stage III Gastric Cancer.Frontiers in oncology · 2020Article
- Clinical significance of serum markers reflecting gastric function andJournal of Cancer · 2019Article
- The relation of microsatellite instability to expression of hTERT in human gastric carcinoma.International journal of clinical and experimental pathology · 2019Article
- Microsatellite instability in gastric cancer: molecular bases, clinical perspectives, and new treatment approaches.Cellular and molecular life sciences : CMLS · 2018Review
- Association between Mismatch-repair Genetic variation and the Risk of Multiple Primary Cancers: A Meta-Analysis.Journal of Cancer · 2017Article
- Diagnostic, Predictive, Prognostic, and Therapeutic Molecular Biomarkers in Third Millennium: A Breakthrough in Gastric Cancer.BioMed research international · 2017Review
- Microsatellite Instability of Gastric and Colorectal Cancers as a Predictor of Synchronous Gastric or Colorectal Neoplasms.Gut and liver · 2016Article
- Usefulness of Immunohistochemistry for Microsatellite Instability Screening in Gastric Cancer.Gut and liver · 2015Article
- ARID1A expression in gastric adenocarcinoma: clinicopathological significance and correlation with DNA mismatch repair status.World journal of gastroenterology · 2015Observational
- Characteristics of metachronous gastric tumors after endoscopic submucosal dissection for gastric intraepithelial neoplasms.Gastroenterology research and practice · 2014Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeReplication error is an important mechanism in carcinogenesis. The microsatellite instability (MSI-H) of colorectal cancers is associated with the development of multiple cancers. The influence of MSI-H on the development of multiple gastric cancers in sporadic gastric cancer patients has not been defined. This study was performed to reveal the association between the clinicopathologic features and MSI in sporadic gastric cancers. MATERIALS AND
methodsBetween July 2004 and March 2009, the clinicopathologic characteristics, including MSI status, were evaluated in 128 consecutive patients with sporadic gastric cancers. None of the patients had hereditary non-polyposis colorectal cancer of familial gastric cancer. The markers that were recommended by the NCI to determine the MSI status for colorectal cancers were used.
resultsMSI-H cancers were found in 10.9% of the patients (14/128). Synchronous gastric cancers were shown in 4 patients (3.1%). Synchronous cancers were found in 2 of 14 patients with MSI-H gastric cancer (14.3%) and 2 of 114 patients with MSS gastric cancer (1.8%; P=0.059, Fisher's exact test). Among the patients with synchronous cancer 50% (2/4) had MSI-H cancer, but 9.7% of the patients (12/124) without synchronous cancer had MSI-H cancer. MSI-H (RR, 24.7; 95% CI, 1.5~398.9; P=0.024) was related with to synchronous gastric cancer, but age, gender, family history, histologic type, location, gross morphology, size, and stage were not related to synchronous gastric cancer.
conclusionsMSI is associated with the intestinal-type gastric cancer and the presence of multiple gastric cancers in patients with sporadic gastric cancer. Special attention to the presence of synchronous and the development of metachronous multiple cancer in patients with MSI-H gastric cancer is needed.
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