ArticlePloS one2011
An in vivo polymicrobial biofilm wound infection model to study interspecies interactions.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 189 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
189 citing papers in PubMed.
- Engineering in vitro models to replicate the complexity of chronic wounds.Nature communications · 2026Review
- Biological and clinical significance of iron inJournal of bacteriology · 2026Review
- Article
- Optimization ofInternational journal of molecular sciences · 2026Article
- Article
- Revealing community dynamics in polymicrobial infections through a quantitative framework.ISME communications · 2026Article
- Metagenomic and Phenotypic Insights Into Biofilm-Forming Pathogens in Patients With Nosocomial Sepsis.BioMed research international · 2026Article
- Hydrogel dressing containing natural extracts inhibits dual-species biofilms of Staphylococcus aureus and Acinetobacter baumannii in ex vivo wound infection models.Scientific reports · 2025Article
- Calprotectin protectsmSystems · 2025Article
- Phage steering in the presence of a competing bacterial pathogen.Microbiology spectrum · 2025Article
- Characteristic of Virulence and Parameters of Mixed Biofilm Formed by Carbapenem-ResistantPathogens (Basel, Switzerland) · 2025Article
- Insights into ecology, pathogenesis, and biofilm formation ofMicrobiology and molecular biology reviews : MMBR · 2025Review
- Article
- Towards improved biofilm models.Nature reviews. Microbiology · 2025Review
- Low-Molecular Weight Branched Polyethylenimine Reduces Cytokine Secretion from Human Immune System Monocytes Stimulated with Bacterial and Fungal PAMPs.ChemMedChem · 2024Article
- Article
- Repurposing Farnesol for Combating Drug-Resistant and Persistent Single and Polymicrobial Biofilms.Antibiotics (Basel, Switzerland) · 2024Article
- Logic programming-based Minimal Cut Sets reveal consortium-level therapeutic targets for chronic wound infections.NPJ systems biology and applications · 2024Article
- Exploiting cooperative pathogen behaviour for enhanced antibiotic potency: A Trojan horse approach.Microbiology (Reading, England) · 2024Article
- Chestnut Honey Is Effective against Mixed Biofilms at Different Stages of Maturity.Antibiotics (Basel, Switzerland) · 2024Article
129 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic wound infections are typically polymicrobial; however, most in vivo studies have focused on monospecies infections. This project was designed to develop an in vivo, polymicrobial, biofilm-related, infected wound model in order to study multispecies biofilm dynamics and in relation to wound chronicity. Multispecies biofilms consisting of both Gram negative and Gram positive strains, as well as aerobes and anaerobes, were grown in vitro and then transplanted onto the wounds of mice. These in vitro-to-in vivo multi-species biofilm transplants generated polymicrobial wound infections, which remained heterogeneous with four bacterial species throughout the experiment. We observed that wounded mice given multispecies biofilm infections displayed a wound healing impairment over mice infected with a single-species of bacteria. In addition, the bacteria in the polymicrobial wound infections displayed increased antimicrobial tolerance in comparison to those in single species infections. These data suggest that synergistic interactions between different bacterial species in wounds may contribute to healing delays and/or antibiotic tolerance.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.