ArticlePloS one2011
Assessing the role of tandem repeats in shaping the genomic architecture of great apes.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 50 citations in OpenAlex.
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- TRACKing tandem repeats: a customizable pipeline for identification and cross-species comparison.Bioinformatics advances · 2025Article
- The burst of satellite DNA in Leptidea wood white butterflies and their putative role in karyotype evolution.DNA research : an international journal for rapid publication of reports on genes and genomes · 2024Article
- Patterns of chromosome evolution in ruminants.Molecular ecology · 2024Article
- Repetitive DNA sequence detection and its role in the human genome.Communications biology · 2023Review
- Mechanisms of Karyotypic Diversification inInternational journal of molecular sciences · 2023Article
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- Evolution of the ancestral mammalian karyotype and syntenic regions.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- 3D chromatin remodelling in the germ line modulates genome evolutionary plasticity.Nature communications · 2022Article
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- Karyotype description and comparative chromosomal mapping of rDNA and U2 snDNA sequences inComparative cytogenetics · 2022Article
- Chromosomal Diversification inFrontiers in genetics · 2022Article
- Evolutionary breakpoint regions and chromosomal remodeling in Harttia (Siluriformes: Loricariidae) species diversification.Genetics and molecular biology · 2022Article
- Highly Rearranged Karyotypes and Multiple Sex Chromosome Systems in Armored Catfishes from the GenusGenes · 2020Article
- Review
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Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAncestral reconstructions of mammalian genomes have revealed that evolutionary breakpoint regions are clustered in regions that are more prone to break and reorganize. What is still unclear to evolutionary biologists is whether these regions are physically unstable due solely to sequence composition and/or genome organization, or do they represent genomic areas where the selection against breakpoints is minimal. METHODOLOGY AND PRINCIPAL
findingsHere we present a comprehensive study of the distribution of tandem repeats in great apes. We analyzed the distribution of tandem repeats in relation to the localization of evolutionary breakpoint regions in the human, chimpanzee, orangutan and macaque genomes. We observed an accumulation of tandem repeats in the genomic regions implicated in chromosomal reorganizations. In the case of the human genome our analyses revealed that evolutionary breakpoint regions contained more base pairs implicated in tandem repeats compared to synteny blocks, being the AAAT motif the most frequently involved in evolutionary regions. We found that those AAAT repeats located in evolutionary regions were preferentially associated with Alu elements. SIGNIFICANCE: Our observations provide evidence for the role of tandem repeats in shaping mammalian genome architecture. We hypothesize that an accumulation of specific tandem repeats in evolutionary regions can promote genome instability by altering the state of the chromatin conformation or by promoting the insertion of transposable elements.
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