ArticlePloS one2011
Age-associated disruption of molecular clock expression in skeletal muscle of the spontaneously hypertensive rat.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
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- Hesperetin Attenuates Experimentally Induced Skeletal Muscle Dysfunction by Modulating Time-of-Day-Dependent Gene Expression and Mitochondrial Redox-Related Markers.Antioxidants (Basel, Switzerland) · 2026Article
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- The transcriptional repressor Rev-erbα regulates circadian expression of the astrocyte Fabp7 mRNA.Current research in neurobiology · 2021Article
- Sex Differences Across the Lifespan: A Focus on Cardiometabolism.Journal of women's health (2002) · 2020Article
- Circadian-Like Rhythmicity of Extracellular Brain Glutamate in Epilepsy.Frontiers in neurology · 2020Article
- A single factor dominates the behavior of rhythmic genes in mouse organs.BMC genomics · 2019Article
- Circadian disruption and divergent microbiota acquisition under extended photoperiod regimens in chicken.PeerJ · 2019Article
- Day-Night Oscillation of Atrogin1 and Timing-Dependent Preventive Effect of Weight-Bearing on Muscle Atrophy.EBioMedicine · 2018Article
- Tidal and diel orchestration of behaviour and gene expression in an intertidal mollusc.Scientific reports · 2018Article
- Development and Therapeutic Potential of Small-Molecule Modulators of Circadian Systems.Annual review of pharmacology and toxicology · 2018Review
- Blind Spot for Sedentarism: Redefining the Diseasome of Physical Inactivity in View of Circadian System and the Irisin/BDNF Axis.Frontiers in neurology · 2018Article
- Achilles is a circadian clock-controlled gene that regulates immune function in Drosophila.Brain, behavior, and immunity · 2017Article
- Clock-Enhancing Small Molecules and Potential Applications in Chronic Diseases and Aging.Frontiers in neurology · 2017Review
- Synchronized human skeletal myotubes of lean, obese and type 2 diabetic patients maintain circadian oscillation of clock genes.Scientific reports · 2016Article
- Identification and temporal expression of putative circadian clock transcripts in the amphipod crustaceanPeerJ · 2016Article
- Bone muscle crosstalk targets muscle regeneration pathway regulated by core circadian transcriptional repressors DEC1 and DEC2.BoneKEy reports · 2016Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
It is well known that spontaneously hypertensive rats (SHR) develop muscle pathologies with hypertension and heart failure, though the mechanism remains poorly understood. Woon et al. (2007) linked the circadian clock gene Bmal1 to hypertension and metabolic dysfunction in the SHR. Building on these findings, we compared the expression pattern of several core-clock genes in the gastrocnemius muscle of aged SHR (80 weeks; overt heart failure) compared to aged-matched control WKY strain. Heart failure was associated with marked effects on the expression of Bmal1, Clock and Rora in addition to several non-circadian genes important in regulating skeletal muscle phenotype including Mck, Ttn and Mef2c. We next performed circadian time-course collections at a young age (8 weeks; pre-hypertensive) and adult age (22 weeks; hypertensive) to determine if clock gene expression was disrupted in gastrocnemius, heart and liver tissues prior to or after the rats became hypertensive. We found that hypertensive/hypertrophic SHR showed a dampening of peak Bmal1 and Rev-erb expression in the liver, and the clock-controlled gene Pgc1α in the gastrocnemius. In addition, the core-clock gene Clock and the muscle-specific, clock-controlled gene Myod1, no longer maintained a circadian pattern of expression in gastrocnemius from the hypertensive SHR. These findings provide a framework to suggest a mechanism whereby chronic heart failure leads to skeletal muscle pathologies; prolonged dysregulation of the molecular clock in skeletal muscle results in altered Clock, Pgc1α and Myod1 expression which in turn leads to the mis-regulation of target genes important for mechanical and metabolic function of skeletal muscle.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.