Trial reportGenetics in medicine : official journal of the American College of Medical Genetics2011
Clinical utility of family history for cancer screening and referral in primary care: a report from the Family Healthware Impact Trial.
Trial report in Genetics in medicine : official journal of the American College of Medical Genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 9 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
60 citing papers in PubMed, 9 syntheses or guidelines pooled it, 88 citations in OpenAlex.
- Genetically guided precision medicine clinical decision support tools: a systematic review.Journal of the American Medical Informatics Association : JAMIA · 2024Pooled it
- Decision aids for people facing health treatment or screening decisions.The Cochrane database of systematic reviews · 2024Pooled it
- Leveraging Health Information Technology to Collect Family Cancer History: A Systematic Review and Meta-Analysis.JCO clinical cancer informatics · 2021Pooled it
- Genetic cancer risk assessment in general practice: systematic review of tools available, clinician attitudes, and patient outcomes.The British journal of general practice : the journal of the Royal College of General Practitioners · 2019Pooled it
- Pooled it
- Decision aids for people facing health treatment or screening decisions.The Cochrane database of systematic reviews · 2017Pooled it
- The impact of health information technology on cancer care across the continuum: a systematic review and meta-analysis.Journal of the American Medical Informatics Association : JAMIA · 2016Pooled it
- Cancer risk assessment tools in primary care: a systematic review of randomized controlled trials.Annals of family medicine · 2015Pooled it
- Clinical decision support for genetically guided personalized medicine: a systematic review.Journal of the American Medical Informatics Association : JAMIAPooled it
- Web-based tool for cancer family history collection: A prospective randomized controlled trial.Gynecologic oncology · 2023Trial
- Evaluation of an online family history tool for identifying hereditary and familial colorectal cancer.Familial cancer · 2018Trial
- Intervention Mediators in a Randomized Controlled Trial to Increase Colonoscopy Uptake Among Individuals at Increased Risk of Familial Colorectal Cancer.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2017Trial
- Family Ties: The Role of Family Context in Family Health History Communication About Cancer.Journal of health communication · 2016Trial
- Protocol for the "Implementation, adoption, and utility of family history in diverse care settings" study.Implementation science : IS · 2015Trial
- Impact of family history assessment on communication with family members and health care providers: A report from the Family Healthware™ Impact Trial (FHITr).Preventive medicine · 2015Trial
- Telehealth personalized cancer risk communication to motivate colonoscopy in relatives of patients with colorectal cancer: the family CARE Randomized controlled trial.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2014Trial
- Effectiveness of oncogenetics training on general practitioners' consultation skills: a randomized controlled trial.Genetics in medicine : official journal of the American College of Medical Genetics · 2014Trial
- Observational
- Could a behaviour change intervention be used to address under-recognition of work-related asthma in primary care? A systematic review.BJGP open · 2025Article
- Proactive familial cancer risk assessment: a service development study in UK primary care.BJGP open · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
purposeTo assess the effectiveness of computerized familial risk assessment and tailored messages for identifying individuals for targeted cancer prevention strategies and motivating behavior change.
methodsWe conducted a randomized clinical trial in primary care patients aged 35-65 years using Family Healthware, a self-administered, internet-based tool that collects family history for six common diseases including breast cancer, colon cancer, and ovarian cancer, stratifies risk into three tiers, and provides tailored prevention messages. Cancer screening adherence and consultation were measured at baseline and 6-month follow-up.
resultsOf 3283 participants, 34% were at strong or moderate risk of at least one of the cancers. Family Healthware identified additional participants for whom earlier screening (colon cancer, 4.4%; breast cancer, women ages: 35-39 years, 9%) or genetic assessment (colon cancer, 2.5%; breast cancer, 10%; and ovarian cancer, 4%) may be indicated. Fewer than half were already adherent with risk-based screening. Screening adherence improved for all risk categories with no difference between intervention and control groups. Consultation with specialists did not differ between groups.
conclusionFamily Healthware identified patients for intensified cancer prevention. Engagement of clinicians and patients, integration with clinical decision support, and inclusion of nonfamilial risk factors may be necessary to achieve the full potential of computerized risk assessment.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.