Evidence map›Paper›PMID 22075273›Full record

Trial reportMetabolism: clinical and experimental2012

Short-term walnut consumption increases circulating total adiponectin and apolipoprotein A concentrations, but does not affect markers of inflammation or vascular injury in obese humans with the metabolic syndrome: data from a double-blinded, randomized, placebo-controlled study.

Konstantinos N Aronis, Maria T Vamvini, John P Chamberland, Laura L Sweeney, Aoife M Brennan, Faidon Magkos, Christos S Mantzoros

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Metabolism: clinical and experimental, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 6 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 6 syntheses or guidelines pooled it, 59 citations in OpenAlex.

  1. Effects of Walnut (Juglans regia L.) on Blood Pressure and Endothelial Function in Adults: A Systematic Review and Dose-Response Meta-Analysis.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Konstantinos N AronisDivision of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Maria T Vamvini
John P Chamberland
Laura L Sweeney
Aoife M Brennan
Faidon Magkos
Christos S Mantzoros
Harvard University · USBeth Israel Deaconess Medical Center · USHarokopio University of Athens · GRVA Boston Healthcare System · US

Funding

ZINC STATUS AND T CELL DISORDER IN MILD HUMAN ZINC DEFICIENCYM01RR001032 · NCRR · BETH ISRAEL DEACONESS MEDICAL CENTER · PI MANTZOROS, CHRISTOS S · 1985 to 2008
$32.3M
Leptin and Adipokine PhysiologyK24DK081913 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI MANTZOROS, CHRISTOS S · 2008 to 2020
$1.5M
NCRR NIH HHS M01 RR001032NCRR NIH HHS M01-RR-01032-328840NIDDK NIH HHS DK081913NIDDK NIH HHS K24 DK081913
6 · The paper itself

Abstract

Long-term consumption of walnuts is associated with lower cardiovascular disease risk in epidemiological studies, possibly through improvements in lipid profile and endothelial function. It remains to be elucidated how soon after initiation of walnut consumption beneficial effects on lipid profile and biomarkers of inflammation or vascular injury can be observed. Fifteen obese subjects (9 men and 6 women; age, 58 ± 2.5 years; body mass index, 36.6 ± 1.7 kg/m(2)) with the metabolic syndrome participated as inpatients in a randomized, double-blinded, placebo-controlled crossover study involving short-term placebo or walnut-enriched diet (48 g/d for 4 days). Apolipoproteins and markers of inflammation and vascular injury were measured before and after consumption of the experimental diets. Consumption of walnuts was associated with a statistically significant increase in serum apolipoprotein A concentrations (P = .03), but did not affect circulating levels of fetuin A, resistin, C-reactive protein, serum amyloid A, soluble intercellular adhesion molecules 1 and 3, soluble vascular cell adhesion protein 1, interleukins 6 and 8, tumor necrosis factor α, E-selectin, P-selectin, and thrombomodulin. Four days of walnut consumption (48 g/d) leads to mild increases in apolipoprotein A concentrations, changes that may precede and lead to the beneficial effects of walnuts on lipid profile in obese subjects with the metabolic syndrome.

Indexed as

JuglansAdiponectinalpha-2-HS-GlycoproteinApolipoprotein A-ICell Adhesion MoleculesC-Reactive ProteinCross-Over StudiesDouble-Blind MethodFemaleHumansInterleukinsMaleMetabolic SyndromeMiddle AgedObesityResistinAdiponectinalpha-2-HS-GlycoproteinApolipoprotein A-ICell Adhesion MoleculesC-Reactive ProteinInterleukinsResistinRETN protein, humanSelectinsSerum Amyloid A ProteinThrombomodulinTumor Necrosis Factor-alphaVascular Cell Adhesion Molecule-1

Identifiers

PMID22075273
PMCPMC3645917
OpenAlexW2131862295

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.