Evidence map›Paper›PMID 22075270›Full record

ReviewMetabolism: clinical and experimental2012

The relationship between vitamin D and the renin-angiotensin system in the pathophysiology of hypertension, kidney disease, and diabetes.

Anand Vaidya, Jonathan S Williams

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Metabolism: clinical and experimental, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed, 8 pooled it
6.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

78 citing papers in PubMed, 8 syntheses or guidelines pooled it, 151 citations in OpenAlex.

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  19. Fibroblast Growth Factors in Cardiovascular Disease.Journal of atherosclerosis and thrombosis · 2024
    Review
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18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Anand VaidyaDivision of Endocrinology, Diabetes, and Hypertension, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. avaidya1@partners.org
Jonathan S Williams
Brigham and Women's Hospital · USHarvard University · US

Funding

Vitamin D and Hormonal Mechanisms of Cardiovascular Disease in ObesityK23HL111771 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI VAIDYA, ANAND · 2012 to 2016
$805k
DASH diet, cardiovascular hemodynamics and type II diabetes mellitusK23HL084236 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI WILLIAMS, JONATHAN S. · 2007 to 2011
$711k
Vitamin D Deficiency Augments Renin-Angiotensin System Activity in ObesityF32HL104776 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI VAIDYA, ANAND · 2010 to 2011
$98k
THE ENANTIOSPECIFIC TOTAL SYNYHESIS OF FORSKOLINF32HL008236 · NHLBI · YALE UNIVERSITY · PI GERVAY-HAGUE, JACQUELYN · 1990 to 1991
–
NHLBI NIH HHS F32 HL104776NHLBI NIH HHS F32HL104776NHLBI NIH HHS K23HL08236-03NHLBI NIH HHS K23 HL084236NHLBI NIH HHS K23 HL111771
6 · The paper itself

Abstract

Vitamin D has been implicated in the pathophysiology of extraskeletal conditions such as hypertension, kidney disease, and diabetes via its ability to negatively regulate the renin-angiotensin system (RAS). This article reviews the evidence supporting a link between vitamin D and the RAS in these conditions, with specific emphasis on translational observations and their limitations. A literature review of animal and human studies evaluating the role of vitamin D in hypertension, kidney disease, and diabetes was performed. Excess activity of the RAS has been implicated in the pathogenesis of hypertension, chronic kidney disease, decreased insulin secretion, and insulin resistance. Animal studies provide strong support for 1,25-dihydroxyvitamin D(3)-mediated downregulation of renin expression and RAS activity via its interaction with the vitamin D receptor. Furthermore, the activity of vitamin D metabolites in animals is associated with reductions in blood pressure, proteinuria and renal injury, and with improved β-cell function. Many observational, and a few interventional, studies in humans have supported these findings; however, there is a lack of well-designed prospective human interventional studies to definitively assess clinical outcomes. There is a need for more well-designed prospective interventional studies to validate this hypothesis in human clinical outcomes.

Indexed as

AnimalsDiabetes MellitusFemaleHumansHypertensionKidney DiseasesMaleModels, AnimalReceptors, CalcitriolRenin-Angiotensin SystemVitamin DReceptors, CalcitriolVitamin D

Identifiers

PMID22075270
PMCPMC3290690
OpenAlexW1978517521

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.