ArticleArteriosclerosis, thrombosis, and vascular biology2012
Inhibitor of differentiation-3 mediates high fat diet-induced visceral fat expansion.
Article in Arteriosclerosis, thrombosis, and vascular biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 40 citations in OpenAlex.
- CT colonography for assessing visceral obesity: clinical utility beyond colorectal screening.Abdominal radiology (New York) · 2026Article
- The role of Id genes on pulmonary hypertension development in left heart failure.American heart journal plus : cardiology research and practice · 2026Article
- A prevalent disease-associated SNP in the humanNAR molecular medicine · 2026Article
- Sex hormone-binding globulin controls sex-specific lipolytic activity in human abdominal subcutaneous adipocytes.Molecular metabolism · 2025Article
- Pathophysiological Features of Remodeling in Vascular Diseases: Impact of Inhibitor of DNA-Binding/Differentiation-3 and Estrogenic Endocrine Disruptors.Medical sciences (Basel, Switzerland) · 2024Review
- B cell contribution to immunometabolic dysfunction and impaired immune responses in obesity.Clinical and experimental immunology · 2022Article
- Loss of Id3 (Inhibitor of Differentiation 3) Increases the Number of IgM-Producing B-1b Cells in Ischemic Skeletal Muscle Impairing Blood Flow Recovery During Hindlimb Ischemia.Arteriosclerosis, thrombosis, and vascular biology · 2022Article
- Estradiol-driven metabolism in transwomen associates with reduced circulating extracellular vesicle microRNA-224/452.European journal of endocrinology · 2021Article
- Helix-Loop-Helix Factor Id3 (Inhibitor of Differentiation 3): A Novel Regulator of Hyaluronan-Mediated Adipose Tissue Inflammation.Arteriosclerosis, thrombosis, and vascular biology · 2021Article
- Role ofMolecular vision · 2020Article
- The Metabolic Syndrome Does Not Affect Development of Collateral Circulation in the Poststenotic Swine Kidney.American journal of hypertension · 2018Article
- Chemerin: a multifaceted adipokine involved in metabolic disorders.The Journal of endocrinology · 2018Review
- Emerging Roles for Adipose Tissue in Cardiovascular Disease.Arteriosclerosis, thrombosis, and vascular biology · 2018Review
- Matriptase-2 deficiency protects from obesity by modulating iron homeostasis.Nature communications · 2018Article
- Inhibitor of Differentiation-3 and Estrogenic Endocrine Disruptors: Implications for Susceptibility to Obesity and Metabolic Disorders.BioMed research international · 2018Review
- ID3 regulates the MDC1-mediated DNA damage response in order to maintain genome stability.Nature communications · 2017Article
- Interrogating islets in health and disease with single-cell technologies.Molecular metabolism · 2017Review
- Contribution of Inhibitor of DNA Binding/Differentiation-3 and Endocrine Disrupting Chemicals to Pathophysiological Aspects of Chronic Disease.BioMed research international · 2017Review
- Protective Role for B-1b B Cells and IgM in Obesity-Associated Inflammation, Glucose Intolerance, and Insulin Resistance.Arteriosclerosis, thrombosis, and vascular biology · 2016Article
- Heterogeneity of white adipose tissue: molecular basis and clinical implications.Experimental & molecular medicine · 2016Review
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
objectiveInhibitor of differentiation-3 (Id3) has been implicated in promoting angiogenesis, a key determinant of high-fat diet (HFD)-induced visceral adiposity. Yet the role of Id3 in HFD-induced angiogenesis and visceral adipose expansion is unknown. METHODS AND
resultsId3(-/-) mice demonstrated a significant attenuation of HFD-induced visceral fat depot expansion compared to wild type littermate controls. Importantly, unlike other Id proteins, loss of Id3 did not affect adipose depot size in young mice fed chow diet or differentiation of adipocytes in vitro or in vivo. Contrast enhanced ultrasound revealed a significant attenuation of visceral fat microvascular blood volume in HFD-fed mice null for Id3 compared to wild type controls. HFD induced Id3 and VEGFA expression in the visceral stromal vascular fraction and Id3(-/-) mice had significantly lower levels of VEGFA protein in visceral adipose tissue compared to wild type. Furthermore, HFD-induced VEGFA expression in visceral adipose tissue was completely abolished by loss of Id3. Consistent with this effect, Id3 abolished E12-mediated repression of VEGFA promoter activity.
conclusionsResults identify Id3 as an important regulator of HFD-induced visceral adipose VEGFA expression, microvascular blood volume, and depot expansion. Inhibition of Id3 may have potential as a therapeutic strategy to limit visceral adiposity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.