ArticleBrain & development2012
A perfusion-metabolic mismatch in Sturge-Weber syndrome: a multimodality imaging study.
Article in Brain & development, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- Beyond the leptomeningeal angioma: a comprehensive review of MR imaging features of Sturge-Weber Syndrome, from early vascular responses to tissue necrosis.Pediatric radiology · 2025Review
- A Review of Sturge-Weber Syndrome Brain Involvement, Cannabidiol Treatment and Molecular Pathways.Molecules (Basel, Switzerland) · 2024Review
- Arterial spin-labeled (ASL) perfusion in children with Sturge-Weber syndrome: a retrospective cross-sectional study.Neuroradiology · 2023Article
- Sturge-Weber syndrome: Updates in pathogenesis, diagnosis, and treatment.Annals of the Child Neurology Society · 2023Review
- A review of the natural history of Sturge-Weber syndrome through adulthood.Journal of neurology · 2022Review
- Reliability and Clinical Correlation of Transcranial Doppler Ultrasound in Sturge-Weber Syndrome.Pediatric neurology · 2017Article
- Imaging increased glutamate in children with Sturge-Weber syndrome: Association with epilepsy severity.Epilepsy research · 2016Article
- Epileptogenesis in neurocutaneous disorders with focus in Sturge Weber syndrome.F1000Research · 2016Review
- Neuroimaging of phakomatoses: overview and advances.Pediatric radiology · 2015Review
- New vascular classification of port-wine stains: improving prediction of Sturge-Weber risk.The British journal of dermatology · 2014Article
- Polymicrogyria: pathology, fetal origins and mechanisms.Acta neuropathologica communications · 2014Review
- Spontaneous Resolution of Drug-Resistant Epilepsy in Patients with Sturge-Weber Syndrome.Child neurology openArticle
- Cerebral venous collaterals: A new fort for fighting ischemic stroke?Progress in neurobiologyReview
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
objectiveWe combined perfusion weighted imaging (PWI) with 2-deoxy-2[(18)F]fluoro-D-glucose (FDG) positron emission tomography (PET) to study the relationship between regional metabolic and perfusion abnormalities and their clinical correlates in children with Sturge-Weber syndrome (SWS).
methodsFifteen children (age: 0.9-10 years) with unilateral SWS underwent high-resolution PWI and FDG PET prospectively. Regional (lobar) asymmetry indices (AIs) of subcortical white matter (WM) cerebral blood flow (CBF) were correlated with corresponding cortical FDG uptake asymmetries, extent of leptomeningeal vascular malformation and clinical seizure variables.
resultsAbnormal cortical glucose metabolism and/or subcortical WM CBF were seen in all lobes affected by vascular malformation and extended to lobes not affected by abnormal pial vessels in 6 patients. Lower CBF was associated with lower cortical glucose metabolism in the temporal, parietal and occipital lobes (p≤0.02). While decreased perfusion was associated with hypometabolism in most cases, increased regional CBF (found in 6 patients) was commonly associated with relatively mild or no hypometabolism. Ten of 24 cerebral lobes with normal glucose metabolism in the affected hemisphere showed abnormal perfusion. High seizure frequency was associated with severe parieto-occipital hypoperfusion (p≤0.03), while long duration of epilepsy was related to frontal lobe hypometabolism (p=0.015).
conclusionsRegional perfusion and cortical metabolic abnormalities can extend beyond lobes affected by leptomeningeal vascular malformations and are related to epilepsy in SWS. Despite a general correlation between perfusion and metabolism, increased WM perfusion with preserved cortical metabolism in overlying cortex is a common pattern of a perfusion/metabolic mismatch. This may represent a disease stage where cortical function is preserved while increased WM perfusion provides collateral drainage of cortex via the deep vein system.
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