ArticleMicrobiology (Reading, England)2012
Fumarate reductase is a major contributor to the generation of reactive oxygen species in the anaerobe Bacteroides fragilis.
Article in Microbiology (Reading, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 42 citations in OpenAlex.
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- Mycobacterium bovis frd operon phase variation hijacks succinate signaling to drive immunometabolic rewiring and pathogenicity.Nature communications · 2025Article
- Transcriptome analysis of aerotolerant and aerosensitiveFrontiers in microbiology · 2025Article
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- Aerobic Conditions and Endogenous Reactive Oxygen Species Reduce the Production of Infectious MS2 Phage byViruses · 2021Article
- Do reactive oxygen species or does oxygen itself confer obligate anaerobiosis? The case of Bacteroides thetaiotaomicron.Molecular microbiology · 2020Article
- Genetic and Biochemical Analysis of Anaerobic Respiration in Bacteroides fragilis and Its ImportancemBio · 2020Article
- Endogenous superoxide is a key effector of the oxygen sensitivity of a model obligate anaerobe.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Article
- H2O2 production rate in Lactobacillus johnsonii is modulated via the interplay of a heterodimeric flavin oxidoreductase with a soluble 28 Kd PAS domain containing protein.Frontiers in microbiology · 2015Article
- The recA operon: A novel stress response gene cluster in Bacteroides fragilis.Research in microbiology · 2014Article
- The impairment of methylmenaquinol:fumarate reductase affects hydrogen peroxide susceptibility and accumulation in Campylobacter jejuni.MicrobiologyOpen · 2014Article
- An anaerobic bacterium, Bacteroides thetaiotaomicron, uses a consortium of enzymes to scavenge hydrogen peroxide.Molecular microbiology · 2013Article
- Ferritin-like family proteins in the anaerobe Bacteroides fragilis: when an oxygen storm is coming, take your iron to the shelter.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2013Article
- Respiratory proteins contribute differentially to Campylobacter jejuni's survival and in vitro interaction with hosts' intestinal cells.BMC microbiology · 2012Article
- Inactivation of a single gene enables microaerobic growth of the obligate anaerobe Bacteroides fragilis.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Metabolic selection of a homologous recombination-mediated gene loss protects Trypanosoma brucei from ROS production by glycosomal fumarate reductase.The Journal of biological chemistryArticle
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2 authors at 1 institution in 1 country.
Funding
Abstract
Despite the detrimental role that endogenously generated reactive oxygen species (ROS) may play in bacteria exposed to aerobic environments, very few sources of ROS have been identified in vivo. Such studies are often precluded by the presence of efficient ROS-scavenging pathways, like those found in the aerotolerant anaerobe Bacteroides fragilis. Here we demonstrate that deletion of the genes encoding catalase (Kat), alkylhydroperoxide reductase (AhpC) and thioredoxin-dependent peroxidase (Tpx) strongly inhibits H(2)O(2) detoxification in B. fragilis, thereby allowing for the quantification of ROS production. Exogenous fumarate significantly reduced H(2)O(2) production in a ΔahpCΔkatΔtpx B. fragilis strain, as did deletion of fumarate reductase subunit c (frdC). Deletion of frdC also increased the aerotolerance of a strain lacking superoxide dismutase, indicating that fumarate reductase is a major contributor to ROS formation in B. fragilis exposed to oxygen.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.