ReviewThe Journal of biological chemistry2012
Melanopsin and mechanisms of non-visual ocular photoreception.
Review in The Journal of biological chemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 74 citations in OpenAlex.
- Traceless Regulation of Genetic Circuitry.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Photobehaviours guided by simple photoreceptor systems.Animal cognition · 2023Review
- Functional connectivity of brain networks with three monochromatic wavelengths: a pilot study using resting-state functional magnetic resonance imaging.Scientific reports · 2022Article
- The Development and Application of Opto-Chemical Tools in the Zebrafish.Molecules (Basel, Switzerland) · 2022Review
- Impacts of vitamin A deficiency on biological rhythms: Insights from the literature.Frontiers in nutrition · 2022Review
- Violet light suppresses lens-induced myopia via neuropsin (OPN5) in mice.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Article
- When is a proxy not a proxy? The foibles of studying non-image forming light.The Journal of physiology · 2018Article
- Melanopsin Contributions to the Representation of Images in the Early Visual System.Current biology : CB · 2017Article
- Animal Cryptochromes: Divergent Roles in Light Perception, Circadian Timekeeping and Beyond.Photochemistry and photobiology · 2017Review
- Mechanisms and applications of the anti-inflammatory effects of photobiomodulation.AIMS biophysics · 2017Article
- Prolonged Inner Retinal Photoreception Depends on the Visual Retinoid Cycle.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Light-sensitive brain pathways and aging.Journal of physiological anthropology · 2016Review
- Light and the evolution of vision.Eye (London, England) · 2016Review
- Human melanopsin-AAV2/8 transfection to retina transiently restores visual function in rd1 mice.International journal of ophthalmology · 2016Article
- Type I intrinsically photosensitive retinal ganglion cells of early post-natal development correspond to the M4 subtype.Neural development · 2015Article
- A tablet that shifts the clock.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- The force-from-lipid (FFL) principle of mechanosensitivity, at large and in elements.Pflugers Archiv : European journal of physiology · 2015Review
- G-Protein Coupled Receptor Kinase 2 Minimally Regulates Melanopsin Activity in Intrinsically Photosensitive Retinal Ganglion Cells.PloS one · 2015Article
- Molecular approaches for manipulating astrocytic signaling in vivo.Frontiers in cellular neuroscience · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
In addition to rods and cones, the mammalian eye contains a third class of photoreceptor, the intrinsically photosensitive retinal ganglion cell (ipRGC). ipRGCs are heterogeneous irradiance-encoding neurons that primarily project to non-visual areas of the brain. Characteristics of ipRGC light responses differ significantly from those of rod and cone responses, including depolarization to light, slow on- and off-latencies, and relatively low light sensitivity. All ipRGCs use melanopsin (Opn4) as their photopigment. Melanopsin resembles invertebrate rhabdomeric photopigments more than vertebrate ciliary pigments and uses a G(q) signaling pathway, in contrast to the G(t) pathway used by rods and cones. ipRGCs can recycle chromophore in the absence of the retinal pigment epithelium and are highly resistant to vitamin A depletion. This suggests that melanopsin employs a bistable sequential photon absorption mechanism typical of rhabdomeric opsins.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.