Evidence map›Paper›PMID 22074921›Full record

ReviewThe Journal of biological chemistry2012

Chemistry and biology of vision.

Krzysztof Palczewski

Open access · hybridAbstract readReview
In one paragraph

Review in The Journal of biological chemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 142 papers.

0numbers the graph read from it
0cells of the map it votes in
142citing papers in PubMed
9.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

142 citing papers in PubMed, 280 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Illuminating retinoid flux in the neurosensory retina.The Journal of clinical investigation · 2026
    Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Molecular properties of a viral heliorhodopsin, V2HeR2.Biophysics and physicobiology · 2025
    Article
  12. Review
  13. Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. Review
  19. The Luminescence Hypothesis of Olfaction.Sensors (Basel, Switzerland) · 2023
    Article
  20. Review

82 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Krzysztof PalczewskiDepartment of Pharmacology, Case Western Reserve University, Cleveland, Ohio 44106, USA. kxp65@case.edu
Case Western Reserve University · US

Funding

STRUCTURAL STUDIES OF ARRESTINSR01EY009339 · NEI · UNIVERSITY OF WASHINGTON · PI KISER, PHILIP DAVID, PALCZEWSKI, KRZYSZTOF · 1992 to 2025
$16.0M
REGULATION OF RHODOPSIN KINASE AND GUANYLATE CYCLASER01EY008061 · NEI · UNIVERSITY OF WASHINGTON · PI PALCZEWSKI, KRZYSZTOF · 1994 to 2014
$9.5M
NEI NIH HHS R01 EY008061NEI NIH HHS R01 EY009339
6 · The paper itself

Abstract

Visual perception in humans occurs through absorption of electromagnetic radiation from 400 to 780 nm by photoreceptors in the retina. A photon of visible light carries a sufficient amount of energy to cause, when absorbed, a cis,trans-geometric isomerization of the 11-cis-retinal chromophore, a vitamin A derivative bound to rhodopsin and cone opsins of retinal photoreceptors. The unique biochemistry of these complexes allows us to reliably and reproducibly collect continuous visual information about our environment. Moreover, other nonconventional retinal opsins such as the circadian rhythm regulator melanopsin also initiate light-activated signaling based on similar photochemistry.

Indexed as

PhotonsAnimalsCircadian RhythmCone OpsinsHumansMelanopsinMicePhotoreceptor Cells, VertebrateRetinaldehydeRhodopsinRod OpsinsVision, OcularVisual PerceptionCone OpsinsMelanopsinRetinaldehydeRhodopsinRod Opsins

Identifiers

PMID22074921
PMCPMC3265841
OpenAlexW1987644884

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.