ArticleProceedings of the National Academy of Sciences of the United States of America2011
Interspecies interactions that result in Bacillus subtilis forming biofilms are mediated mainly by members of its own genus.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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Who cites it
58 citing papers in PubMed, 117 citations in OpenAlex.
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- Deconstruction of a multi-strain Bacillus-based probiotic used for poultry: an in vitro assessment of its individual components against C. perfringens.BMC research notes · 2023Article
- Reprogramming of phytopathogen transcriptome by a non-bactericidal pesticide residue alleviates its virulence in rice.Fundamental research · 2022Article
- Resolving the conflict between antibiotic production and rapid growth by recognition of peptidoglycan of susceptible competitors.Nature communications · 2022Article
- Lipopeptide Interplay Mediates Molecular Interactions between Soil Bacilli and Pseudomonads.Microbiology spectrum · 2021Article
- Bacillus subtilis biofilm formation and social interactions.Nature reviews. Microbiology · 2021Review
- Skin microbiota dynamics following B. subtilis formulation challenge: an in vivo study in mice.BMC microbiology · 2021Article
- Three-dimensional biofilm colony growth supports a mutualism involving matrix and nutrient sharing.eLife · 2021Article
- Interactions BetweenFrontiers in microbiology · 2021Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Many different systems of bacterial interactions have been described. However, relatively few studies have explored how interactions between different microorganisms might influence bacterial development. To explore such interspecies interactions, we focused on Bacillus subtilis, which characteristically develops into matrix-producing cannibals before entering sporulation. We investigated whether organisms from the natural environment of B. subtilis--the soil--were able to alter the development of B. subtilis. To test this possibility, we developed a coculture microcolony screen in which we used fluorescent reporters to identify soil bacteria able to induce matrix production in B. subtilis. Most of the bacteria that influence matrix production in B. subtilis are members of the genus Bacillus, suggesting that such interactions may be predominantly with close relatives. The interactions we observed were mediated via two different mechanisms. One resulted in increased expression of matrix genes via the activation of a sensor histidine kinase, KinD. The second was kinase independent and conceivably functions by altering the relative subpopulations of B. subtilis cell types by preferentially killing noncannibals. These two mechanisms were grouped according to the inducing strain's relatedness to B. subtilis. Our results suggest that bacteria preferentially alter their development in response to secreted molecules from closely related bacteria and do so using mechanisms that depend on the phylogenetic relatedness of the interacting bacteria.
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