ArticleNeurobiology of aging2012
Age-associated loss of selectivity in human olfactory sensory neurons.
Article in Neurobiology of aging, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 61 citations in OpenAlex.
- When Familiar Faces Feel Better: A Framework for Social Neurocognitive Aging in a Rat Model.eNeuro · 2026Article
- Sensory Insights in Aging: Exploring the Impact on Improving Dietary Through Sensory Enhancement.Food science & nutrition · 2025Review
- Article
- Integrating the patient's voice into the research agenda for treatment of chemosensory disorders.Chemical senses · 2024Article
- Reduction in the olfactory ability in agingFrontiers in aging · 2024Article
- Natural and Pathological Aging Distinctively Impacts the Pheromone Detection System and Social Behavior.Molecular neurobiology · 2023Article
- Shedding light on human olfaction: Electrophysiological recordings from sensory neurons in acute slices of olfactory epithelium.iScience · 2023Article
- International consensus statement on allergy and rhinology: Olfaction.International forum of allergy & rhinology · 2022Review
- The Olfactory System as Marker of Neurodegeneration in Aging, Neurological and Neuropsychiatric Disorders.International journal of environmental research and public health · 2021Review
- Olfactory impairment in men and mice related to aging and amyloid-induced pathology.Pflugers Archiv : European journal of physiology · 2021Review
- Taste and smell function in Wolfram syndrome.Orphanet journal of rare diseases · 2020Article
- Aging Alters Olfactory Bulb Network Oscillations and Connectivity: Relevance for Aging-Related Neurodegeneration Studies.Neural plasticity · 2020Article
- Age-Related Olfactory Dysfunction: Epidemiology, Pathophysiology, and Clinical Management.Frontiers in aging neuroscience · 2020Review
- Stable olfactory sensory neuron in vivo physiology during normal aging.Neurobiology of aging · 2018Article
- Contrasting olfaction, vision, and audition as predictors of cognitive change and impairment in non-demented older adults.Neuropsychology · 2018Article
- Early Aging Effect on the Function of the Human Central Olfactory System.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Article
- Variant in a common odorant-binding protein gene is associated with bitter sensitivity in people.Behavioural brain research · 2017Article
- Office-based olfactory mucosa biopsies.International forum of allergy & rhinology · 2016Article
- Article
- Inflammatory and vascular markers and olfactory impairment in older adults.Age and ageing · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 5 institutions in 1 country.
Funding
Abstract
We report a cross-sectional study of olfactory impairment with age based on both odorant-stimulated responses of human olfactory sensory neurons (OSNs) and tests of olfactory threshold sensitivity. A total of 621 OSNs from 440 subjects in 2 age groups of younger (≤ 45 years) and older (≥ 60 years) subjects were investigated using fluorescence intensity ratio fura-2 imaging. OSNs were tested for responses to 2 odorant mixtures, as well as to subsets of and individual odors in those mixtures. Whereas cells from younger donors were highly selective in the odorants to which they responded, cells from older donors were more likely to respond to multiple odor stimuli, despite a loss in these subjects' absolute olfactory sensitivity, suggesting a loss of specificity. This degradation in peripheral cellular specificity may impact odor discrimination and olfactory adaptation in the elderly. It is also possible that chronic adaptation as a result of reduced specificity contributes to observed declines in absolute sensitivity.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.