ArticleThe journal of pain2011
Potential autonomic risk factors for chronic TMD: descriptive data and empirically identified domains from the OPPERA case-control study.
Article in The journal of pain, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
60 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Usefulness of the Pressure Algometer in the Diagnosis and Treatment of Orofacial Pain Patients: A Systematic Review.Occupational therapy international · 2020Pooled it
- Effect of comorbid migraine on propranolol efficacy for painful TMD in a randomized controlled trial.Cephalalgia : an international journal of headache · 2021Trial
- Trial
- Association Between Psychological Factors and Masticatory Muscle Thickness Assessed by Ultrasonography in Female Dental Students with TMD-Related Myalgia: A Cross-Sectional Study.Journal of clinical medicine · 2026Article
- Temporomandibular disorder as an indicator of altered physiological stress reactivity: a highly standardized experimental protocol.BMC oral health · 2026Article
- Nocturnal Autonomic Nervous System Dynamics and Chronic Painful Temporomandibular Disorders.JDR clinical and translational research · 2026Observational
- Association Between Chronic Pain and Risk of Glaucoma: A Prospective Cohort Study.Translational vision science & technology · 2025Article
- Contribution of Sympathetic Sensory Coupling to Craniofacial Nociception.Orthodontics & craniofacial research · 2025Review
- Preclinical perspectives on disorders of the temporomandibular joint: Tracing the past, navigating the present, and shaping the future.The journal of pain · 2025Review
- Association Between Cardiovascular Autonomic Function and Temporomandibular Disorders.Journal of oral rehabilitation · 2025Article
- Tell me what to expect: how instructions affect the pain response of patients with chronic myofascial pain with referral.Journal of oral & facial pain and headache · 2024Article
- Impact of applying different levels of threshold-based artifact correction on the processing of heart rate variability data in individuals with temporomandibular disorder.Scientific reports · 2024Observational
- Short-term heart rate variability at rest in individuals with temporomandibular disorder: a comparative analysis.Clinical oral investigations · 2023Observational
- Sensory Neuron-TRPV4 Modulates Temporomandibular Disorder Pain Via CGRP in Mice.The journal of pain · 2023Review
- Effects of Malocclusion on Maximal Aerobic Capacity and Athletic Performance in Young Sub-Elite Athletes.Sports (Basel, Switzerland) · 2023Article
- Article
- Associations between obstructive sleep apnea and painful temporomandibular disorder: a systematic review.Journal of the Korean Association of Oral and Maxillofacial Surgeons · 2022Review
- Potential Role of Obstructive Sleep Apnea on Pain Sensitization and Jaw Function in Temporomandibular Disorder Patients.Journal of Korean medical science · 2022Article
- Photosensitivity Is Associated with Chronic Pain following Traumatic Brain Injury.Journal of neurotrauma · 2022Article
- Regulatory Emotional Self-Efficacy Buffers the Effect of Heart Rate Variability on Functional Capacity in Older Adults With Chronic Low Back Pain.Frontiers in pain research (Lausanne, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
unlabelledSeveral case-control studies have been conducted that examine the association between autonomic variables and persistent pain conditions; however, there is a surprising dearth of published studies in this area that have focused on temporomandibular disorders (TMD). The current study presents autonomic findings from the baseline case-control study of the OPPERA (Orofacial Pain: Prospective Evaluation and Risk Assessment) cooperative agreement. Measures of arterial blood pressure, heart rate, heart rate variability, and indirect measures of baroreflex sensitivity were assessed at rest and in response to a physical (orthostatic) and psychological (Stroop) stressors in 1,633 TMD-free controls and 185 TMD cases. In bivariate and demographically adjusted analyses, greater odds of TMD case status were associated with elevated heart rates, reduced heart rate variability, and reduced surrogate measures of baroreflex sensitivity across all experimental procedures. Principal component analysis was undertaken to identify latent constructs revealing 5 components. These findings provide evidence of associations between autonomic factors and TMD. Future prospective analyses in the OPPERA cohort will determine if the presence of these autonomic factors predicts increased risk for developing new onset TMD. PERSPECTIVE: This article reports autonomic findings from the OPPERA Study, a large prospective cohort study designed to discover causal determinants of TMD pain. Findings indicate statistically significant differences between TMD cases and controls across multiple autonomic constructs at rest and during both physical and psychologically challenging conditions. Future analyses will determine whether these autonomic factors increase risk for new onset TMD.
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