ArticlePlant physiology2012
Redox states of plastids and mitochondria differentially regulate intercellular transport via plasmodesmata.
Article in Plant physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed, 119 citations in OpenAlex.
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- The Contribution of Phloem Metabolism to Leaf Respiration: New Insights Into an Old Problem.Plant, cell & environment · 2026Article
- Plasmodesmata display dynamic local and systemic redox responses during plant stress.The Plant cell · 2026Article
- Robust quantification of multiplexed fluorescent protein-based biosensors in plant tissues.The Plant journal : for cell and molecular biology · 2026Article
- Three decades of mobile RNA silencing within plants: what have we learnt?Journal of experimental botany · 2026Review
- Glucosinolates can act as signals to modulate intercellular trafficking via plasmodesmata.The New phytologist · 2025Article
- Distributing Plant Developmental Regulatory Proteins via Plasmodesmata.Plants (Basel, Switzerland) · 2024Review
- Article
- Communicating Across Cell Walls: Structure, Evolution, and Regulation of Plasmodesmatal Transport in Plants.Results and problems in cell differentiation · 2024Review
- Metabolic regulation of quiescence in plants.The Plant journal : for cell and molecular biology · 2023Article
- Chloroplast redox state changes mark cell-to-cell signaling in the hypersensitive response.The New phytologist · 2023Article
- Leaf vein patterning is regulated by the aperture of plasmodesmata intercellular channels.PLoS biology · 2022Article
- Intertwined Roles of Reactive Oxygen Species and Salicylic Acid Signaling Are Crucial for the Plant Response to Biotic Stress.International journal of molecular sciences · 2022Review
- Quantifying Plasmodesmatal Transport with an Improved GFP Movement Assay.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Investigating Plasmodesmata Function in Arabidopsis Thaliana Using a Low-Pressure Bombardment System and GFP Movement Assay.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Function of Plasmodesmata in the Interaction of Plants with Microbes and Viruses.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Measuring ROS and redox markers in plant cells.RSC chemical biology · 2021Review
- Biosensors: A Sneak Peek into Plant Cell's Immunity.Life (Basel, Switzerland) · 2021Review
- Are Flavonoids Effective Antioxidants in Plants? Twenty Years of Our Investigation.Antioxidants (Basel, Switzerland) · 2020Review
- Exaptive Evolution of Target of Rapamycin Signaling in Multicellular Eukaryotes.Developmental cell · 2020Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Recent studies suggest that intercellular transport via plasmodesmata (PD) is regulated by cellular redox state. Until now, this relationship has been unclear, as increased production of reactive oxygen species (ROS) has been associated with both increased and decreased intercellular transport via PD. Here, we show that silencing two genes that both increase transport via PD, INCREASED SIZE EXCLUSION LIMIT1 (ISE1) and ISE2, alters organelle redox state. Using redox-sensitive green fluorescent proteins targeted to the mitochondria or plastids, we show that, relative to wild-type leaves, plastids are more reduced in both ISE1- and ISE2-silenced leaves, whereas mitochondria are more oxidized in ISE1-silenced leaves. We further show that PD transport is positively regulated by ROS production in mitochondria following treatment with salicylhydroxamic acid but negatively regulated by an oxidative shift in both chloroplasts and mitochondria following treatment with paraquat. Thus, oxidative shifts in the mitochondrial redox state positively regulate intercellular transport in leaves, but oxidative shifts in the plastid redox state counteract this effect and negatively regulate intercellular transport. This proposed model reconciles previous contradictory evidence relating ROS production to PD transport and supports accumulating evidence that mitochondria and plastids are crucial regulators of PD function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.