ArticleBMC veterinary research2011
Factors associated with the occurrence of MRSA CC398 in herds of fattening pigs in Germany.
Article in BMC veterinary research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Gram-positive ESKAPE pathogens in Germany: A comprehensive analysis of occurrence and resistance development in animal, food, and environmental sources.One health (Amsterdam, Netherlands) · 2025Review
- Intervention strategies for methicillin-resistant Staphylococcus aureus control in pig farming: a comprehensive review.Porcine health management · 2025Review
- Prevalence of Methicillin-ResistantEpidemiologia (Basel, Switzerland) · 2025Review
- Multidrug-ResistantAntibiotics (Basel, Switzerland) · 2024Article
- Development of triplex assay for simultaneous detection ofJournal of food science and technology · 2024Article
- Nasal staphylococci community of healthy pigs and pig-farmers in Aragon (Spain). Predominance and within-host resistome diversity in MRSA-CC398 and MSSA-CC9 lineages.One health (Amsterdam, Netherlands) · 2023Article
- A review of new emerging livestock-associated methicillin-resistantVeterinary world · 2023Review
- Farming Practice Influences Antimicrobial Resistance Burden of Non-Aureus Staphylococci in Pig Husbandries.Microorganisms · 2022Article
- Antimicrobial Resistance and Molecular Characterization of Methicillin-ResistantAntibiotics (Basel, Switzerland) · 2022Article
- Prevalence of LA-MRSA in pigsties: analysis of factors influencing the (De)colonization process.Scientific reports · 2022Article
- The European Union Summary Report on Antimicrobial Resistance in zoonotic and indicator bacteria from humans, animals and food in 2019-2020.EFSA journal. European Food Safety Authority · 2022Article
- Pilot Study on Alteration of LA-MRSA Status of Pigs during Fattening Period on Straw Bedding by Two Types of Cleaning.Antibiotics (Basel, Switzerland) · 2021Article
- Article
- Influence of Immune Status on the Airborne Colonization of Piglets with Methicillin-Resistant Staphylococcus aureus (MRSA) Clonal Complex (CC) 398.European journal of microbiology & immunology · 2020Article
- Methicillin-ResistantFrontiers in microbiology · 2020Article
- Characteristics of methicillin-resistant Staphylococcus aureus from broiler farms in Germany are rather lineage- than source-specific.Poultry science · 2019Article
- Prevalence, molecular epidemiology, and antimicrobial resistance of methicillin-resistant Staphylococcus aureus from swine in southern Italy.BMC microbiology · 2019Article
- Prevalence of methicillin-resistantInfection and drug resistance · 2019Article
- Prevalence of methicillin-resistant Staphylococcus aureus among large commercial pig herds in South Africa.The Onderstepoort journal of veterinary research · 2018Article
- Article
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Authors and funding
14 authors.
Funding
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Abstract
backgroundThe purpose of this study was to investigate the prevalence of MRSA in herds of fattening pigs in different regions of Germany, and to determine factors associated with the occurrence of this pathogen. For this purpose pooled dust samples were collected, and a questionnaire covered information regarding herd characteristics and management practices. Samples were pre-enriched in high-salt medium followed by selective enrichment containing cefoxitin/aztreonam, and culturing. Presumptive colonies were confirmed by multiplex-PCR targeting nuc-, mecA- and 16S rRNA-genes. Isolates were spa- and SCCmec-, and in selected cases, multilocus sequence-typed. Susceptibilities to 13 antimicrobials were determined by broth microdilution. Statistical analysis was carried out using backward stepwise logistic regression to calculate odds ratios with the MRSA test result as the outcome and herd characteristics as categorical covariates.
resultsOverall, 152 of 290 (52%) fattening pig farms tested positive for MRSA. The prevalence in the east, north- and south-west of Germany ranged from 39 to 59%.t011 (66%) and t034 (23%) were the most commonly identified spa-types, and 85% of isolates carried SCCmec Type V. Identified spa-types were all associated with clonal complex CC398. Susceptibility testing revealed that all isolates were resistant to tetracycline. High resistance rates were also found for sulfamethoxazole/trimethoprim (40%), and quinupristin/dalfopristin (32%). In addition, 83% of strains displayed multidrug resistant (> 3 substance classes) phenotypes.Logistic regression revealed herd size (large farms OR: 5.4; CI: 2.7-11.2; p < 0.05), and production type (wean-to-finish OR: 4.0; CI: 1.6-10.4; p < 0.05) as risk factors associated with a positive MRSA finding in fattening pig operations.
conclusionsMRSA CC398 is widely distributed among herds of fattening pigs in Germany. Farm management plays a crucial role in the dissemination of MRSA with herd size, and production type representing potential major indicators.
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