ArticleCough (London, England)2011
Perspective on the human cough reflex.
Article in Cough (London, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.
- Prevalence of chronic cough in China: a systematic review and meta-analysis.BMC pulmonary medicine · 2022Pooled it
- Sweet taste and menthol increase cough reflex thresholds.Pulmonary pharmacology & therapeutics · 2012Trial
- Clarifying Terminology in Chronic Cough: The Evolving Role of Cough Hypersensitivity Syndrome.The clinical respiratory journal · 2026Review
- The lipid language of tuberculosis:mBio · 2026Review
- Sulfolipid-1 fromJournal of neurophysiology · 2026Article
- Article
- Cough Sounds in Screening and Diagnostics: A Scoping Review.The Laryngoscope · 2024Article
- Inhalation Therapy with Nebulized Capsaicin in a Patient with Oropharyngeal Dysphagia Post Stroke: A Clinical Case Report.Geriatrics (Basel, Switzerland) · 2022Article
- Article
- How does homeostasis happen? Integrative physiological, systems biological, and evolutionary perspectives.American journal of physiology. Regulatory, integrative and comparative physiology · 2019Review
- Coughing in Small Animal Patients.Frontiers in veterinary science · 2019Review
- Analysis of the Literature on Chronic Cough in Children.The open respiratory medicine journal · 2017Review
- Chronic cough in Korean adults: a literature review on common comorbidity.Asia Pacific allergy · 2016Review
- Evolution of lung breathing from a lungless primitive vertebrate.Respiratory physiology & neurobiology · 2016Article
- Preliminary Evidence of Reduced Urge to Cough and Cough Response in Four Individuals following Remote Traumatic Brain Injury with Tracheostomy.Canadian respiratory journal · 2016Article
- Chronic cough: an Asian perspective. Part 1: Epidemiology.Asia Pacific allergy · 2015Review
- Cough hypersensitivity as a neuro-immune interaction.Clinical and translational allergy · 2015Review
- Capsaicin cough sensitivity is related to the older female predominant feature in chronic cough patients.Allergy, asthma & immunology research · 2014Article
- Review
- Changing the paradigm for cough: does 'cough hypersensitivity' aid our understanding?Asia Pacific allergy · 2014Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This review dissects the complex human cough reflex and suggests hypotheses about the evolutionary basis for the reflex. A mechanosensory-induced cough reflex conveys through branches of myelinated Aδ nerve fibers is not chemically reactive (i.e., capsaicin, bradykinin); possibly, its evolution is to prevent the harmful effects of aspiration of gastric or particulate contents into the lungs. This became necessary as the larynx moves closer to the opening of the esophagus as human ancestors adapt phonation over olfaction beginning less than 10 million years ago. The second type of cough reflex, a chemosensory type, is carried by unmyelinated C fibers. Supposedly, its origin dates back when prehistoric humans began living in close proximity to each other and were at risk for infectious respiratory diseases or irritant-induced lung injury. The mechanism for the latter type of cough is analogous to induced pain after tissue injury; and, it is controlled by the identical transient receptor potential vanilloid cation channel (TRPV1). The airways do not normally manifest nociceptive pain from a stimulus but the only consistent response that capsaicin and lung inflammation provoke in healthy human airways is cough. TRPA1, another excitatory ion channel, has been referred to as the "irritant receptor" and its activation also induces cough. For both types of cough, the motor responses are identical and via coordinated, precisely-timed and sequential respiratory events orchestrated by complex neuromuscular networking of the diaphragm, chest and abdominal respiratory muscles, the glottis and parts of the brain.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.