Trial reportBMJ (Clinical research ed.)1990
Efficacy of potassium and magnesium in essential hypertension: a double-blind, placebo controlled, crossover study.
Trial report in BMJ (Clinical research ed.), 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 8 syntheses or guidelines pooled it, 84 citations in OpenAlex.
- Effectively Prescribing Oral Magnesium Therapy for Hypertension: A Categorized Systematic Review of 49 Clinical Trials.Nutrients · 2021Pooled it
- Potassium Intake and Blood Pressure: A Dose-Response Meta-Analysis of Randomized Controlled Trials.Journal of the American Heart Association · 2020Pooled it
- Oral potassium supplementation for management of essential hypertension: A meta-analysis of randomized controlled trials.PloS one · 2017Pooled it
- Systematic review: antihypertensive drug therapy in patients of African and South Asian ethnicity.Internal and emergency medicine · 2016Pooled it
- Effect of increased potassium intake on cardiovascular risk factors and disease: systematic review and meta-analyses.BMJ (Clinical research ed.) · 2013Pooled it
- Magnesium supplementation for the management of essential hypertension in adults.The Cochrane database of systematic reviews · 2006Pooled it
- Combined calcium, magnesium and potassium supplementation for the management of primary hypertension in adults.The Cochrane database of systematic reviews · 2006Pooled it
- Lifestyle modifications to prevent and control hypertension. 6. Recommendations on potassium, magnesium and calcium. Canadian Hypertension Society, Canadian Coalition for High Blood Pressure Prevention and Control, Laboratory Centre for Disease Control at Health Canada, Heart and Stroke Foundation of Canada.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 1999Guideline
- Serum potassium predicts time to blood pressure response among African Americans with hypertensive nephrosclerosis.Journal of human hypertension · 2013Trial
- Blood pressure response to changes in sodium and potassium intake: a metaregression analysis of randomised trials.Journal of human hypertension · 2003Trial
- Salty Subjects: Unpacking Racial Differences in Salt-Sensitive Hypertension.Current hypertension reports · 2024Review
- Review
- Acute dairy milk ingestion does not improve nitric oxide-dependent vasodilation in the cutaneous microcirculation.The British journal of nutrition · 2016Article
- Association of hypermagnesemia and blood pressure in the critically ill.Journal of hypertension · 2013Article
- Role of dietary salt and potassium intake in cardiovascular health and disease: a review of the evidence.Mayo Clinic proceedings · 2013Review
- The role of magnesium in hypertension and cardiovascular disease.Journal of clinical hypertension (Greenwich, Conn.) · 2011Review
- Dairy components and risk factors for cardiometabolic syndrome: recent evidence and opportunities for future research.Advances in nutrition (Bethesda, Md.) · 2011Review
- Non-pharmacological aspects of blood pressure management: what are the data?Kidney international · 2011Review
- Strategies for initial management of hypertension.The Indian journal of medical research · 2010Review
- Hypertension.Postgraduate medical journal · 1991Review
Corrections and comments
- Commented on by
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the antihypertensive activity of potassium given alone or in combination with magnesium in patients with mild hypertension.
designA double blind, randomised, placebo controlled, crossover trial of 32 weeks' duration. SETTINGS: Cardiology outpatient department, Sassoon General Hospitals, Pune, India. PATIENTS: 37 Adults with mild hypertension (diastolic blood pressure less than 110 mm Hg).
interventionPatients received either placebo or potassium 60 mmol/day alone or in combination with magnesium 20 mmol/day in a crossover design. No other drug treatment was allowed. MEASUREMENTS: Blood pressure and heart rate assessed at weekly intervals and biochemical parameters at monthly intervals.
resultsPotassium alone or in combination with magnesium produced a significant reduction in systolic and diastolic blood pressures (p less than 0.001) and a significant reduction in serum cholesterol concentration (p less than 0.05); other biochemical variables did not change. Magnesium did not have an additional effect. Urinary potassium excretion increased significantly in the groups who received potassium alone or in combination with magnesium. The drug was well tolerated and compliance was satisfactory.
conclusionPotassium 60 mmol/day lowers arterial blood pressure in patients with mild hypertension. Giving magnesium as well has no added advantage.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.