ArticlePloS one2011
Restrictions in cell cycle progression of adult vestibular supporting cells in response to ectopic cyclin D1 expression.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 33 citations in OpenAlex.
- The Hippo pathway and p27Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Glial-Specific Deletion of Med12 Results in Rapid Hearing Loss via Degradation of the Stria Vascularis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Knockdown ofAging · 2020Article
- EGF and a GSK3 Inhibitor Deplete Junctional E-cadherin and Stimulate Proliferation in the Mature Mammalian Ear.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Cell Cycle Proteins as Key Regulators of Postmitotic Cell Death.The Yale journal of biology and medicine · 2019Review
- Characterization of Adult Vestibular Organs in 11 CreER Mouse Lines.Journal of the Association for Research in Otolaryngology : JARO · 2018Article
- Lateral line placodes of aquatic vertebrates are evolutionarily conserved in mammals.Biology open · 2018Article
- Article
- Development and regeneration of vestibular hair cells in mammals.Seminars in cell & developmental biology · 2017Review
- Regeneration of hair cells in the mammalian vestibular system.Frontiers of medicine · 2016Review
- Cisplatin exposure damages resident stem cells of the mammalian inner ear.Developmental dynamics : an official publication of the American Association of Anatomists · 2014Article
- DNA damage signaling regulates age-dependent proliferative capacity of quiescent inner ear supporting cells.Aging · 2014Article
- Hair cell generation by notch inhibition in the adult mammalian cristae.Journal of the Association for Research in Otolaryngology : JARO · 2013Article
- Ectopic expression of activated notch or SOX2 reveals similar and unique roles in the development of the sensory cell progenitors in the mammalian inner ear.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Heterogeneity of neuroblastoma cell lines in insulin-like growth factor 1 receptor/Akt pathway-mediated cell proliferative responses.Cancer science · 2013Article
- Inner ear supporting cells: rethinking the silent majority.Seminars in cell & developmental biology · 2013Review
- A brief history of hair cell regeneration research and speculations on the future.Hearing research · 2013Review
- A historical to present-day account of efforts to answer the question: "what puts the brakes on mammalian hair cell regeneration?".Hearing research · 2013Review
- Article
- Regenerative medicine for the special senses: restoring the inputs.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Sensory hair cells and supporting cells of the mammalian inner ear are quiescent cells, which do not regenerate. In contrast, non-mammalian supporting cells have the ability to re-enter the cell cycle and produce replacement hair cells. Earlier studies have demonstrated cyclin D1 expression in the developing mouse supporting cells and its downregulation along maturation. In explant cultures of the mouse utricle, we have here focused on the cell cycle control mechanisms and proliferative potential of adult supporting cells. These cells were forced into the cell cycle through adenoviral-mediated cyclin D1 overexpression. Ectopic cyclin D1 triggered robust cell cycle re-entry of supporting cells, accompanied by changes in p27(Kip1) and p21(Cip1) expressions. Main part of cell cycle reactivated supporting cells were DNA damaged and arrested at the G2/M boundary. Only small numbers of mitotic supporting cells and rare cells with signs of two successive replications were found. Ectopic cyclin D1-triggered cell cycle reactivation did not lead to hyperplasia of the sensory epithelium. In addition, a part of ectopic cyclin D1 was sequestered in the cytoplasm, reflecting its ineffective nuclear import. Combined, our data reveal intrinsic barriers that limit proliferative capacity of utricular supporting cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.