ArticlePloS one2011
Oscillatory protein expression dynamics endows stem cells with robust differentiation potential.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Evolution of hierarchy and irreversibility in theoretical cell differentiation model.PNAS nexus · 2024Article
- Self-Regulated Symmetry Breaking Model for Stem Cell Differentiation.Entropy (Basel, Switzerland) · 2023Article
- Novel generic models for differentiating stem cells reveal oscillatory mechanisms.Journal of the Royal Society, Interface · 2021Article
- Article
- Review
- Homeorhesis and ecological succession quantified in synthetic microbial ecosystems.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Prss56 expression in the rodent hypothalamus: Inverse correlation with pro-opiomelanocortin suggests oscillatory gene expression in adult rat tanycytes.The Journal of comparative neurology · 2018Article
- Enhancing coherence via tuning coupling range in nonlocally coupled Stuart-Landau oscillators.Scientific reports · 2018Article
- Reprogramming, oscillations and transdifferentiation in epigenetic landscapes.Scientific reports · 2018Article
- Nanog induced intermediate state in regulating stem cell differentiation and reprogramming.BMC systems biology · 2018Article
- Explosive death induced by mean-field diffusion in identical oscillators.Scientific reports · 2017Article
- Synchronization patterns: from network motifs to hierarchical networks.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2017Article
- Cell signaling as a cognitive process.The EMBO journal · 2017Review
- Synthetic biology routes to bio-artificial intelligence.Essays in biochemistry · 2016Review
- Boosting functionality of synthetic DNA circuits with tailored deactivation.Nature communications · 2016Article
- Pluripotency, Differentiation, and Reprogramming: A Gene Expression Dynamics Model with Epigenetic Feedback Regulation.PLoS computational biology · 2015Article
- Reshaping the epigenetic landscape during early flower development: induction of attractor transitions by relative differences in gene decay rates.BMC systems biology · 2015Article
- Effect of noise in intelligent cellular decision making.PloS one · 2015Article
- Modeling and visualizing cell type switching.Computational and mathematical methods in medicine · 2014Article
- Regulating synthetic gene networks in 3D materials.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
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Authors and funding
3 authors.
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Abstract
The lack of understanding of stem cell differentiation and proliferation is a fundamental problem in developmental biology. Although gene regulatory networks (GRNs) for stem cell differentiation have been partially identified, the nature of differentiation dynamics and their regulation leading to robust development remain unclear. Herein, using a dynamical system modeling cell approach, we performed simulations of the developmental process using all possible GRNs with a few genes, and screened GRNs that could generate cell type diversity through cell-cell interactions. We found that model stem cells that both proliferated and differentiated always exhibited oscillatory expression dynamics, and the differentiation frequency of such stem cells was regulated, resulting in a robust number distribution. Moreover, we uncovered the common regulatory motifs for stem cell differentiation, in which a combination of regulatory motifs that generated oscillatory expression dynamics and stabilized distinct cellular states played an essential role. These findings may explain the recently observed heterogeneity and dynamic equilibrium in cellular states of stem cells, and can be used to predict regulatory networks responsible for differentiation in stem cell systems.
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