ArticlePloS one2011
Genomic ancestry, self-reported "color" and quantitative measures of skin pigmentation in Brazilian admixed siblings.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 93 citations in OpenAlex.
- A systematic literature review on the European, African and Amerindian genetic ancestry components on Brazilian health outcomes.Scientific reports · 2019Pooled it
- Trial
- Genetic ancestry inferred from autosomal and Y chromosome markers and HLA genotypes in Type 1 Diabetes from an admixed Brazilian population.Scientific reports · 2021Article
- Skin deep: The decoupling of genetic admixture levels from phenotypes that differed between source populations.American journal of physical anthropology · 2021Article
- Skin pigmentation polymorphisms associated with increased risk of melanoma in a case-control sample from southern Brazil.BMC cancer · 2020Article
- Glomerular filtration rate estimated by the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation in type 1 diabetes based on genomic ancestry.Diabetology & metabolic syndrome · 2020Article
- Context-dependence of race self-classification: Results from a highly mixed and unequal middle-income country.PloS one · 2019Article
- Influence of genomic ancestry and self-reported color-race in CKD in a nationwide admixed sample of Brazilian patients with type 1 diabetes.Diabetes, metabolic syndrome and obesity : targets and therapy · 2019Article
- Bruch's membrane opening minimum rim width and retinal nerve fiber layer thickness in a Brazilian population of healthy subjects.PloS one · 2018Article
- Article
- African ancestry is associated with facial melasma in women: a cross-sectional study.BMC medical genetics · 2017Article
- Common NOD2/CARD15 and TLR4 Polymorphisms Are Associated with Crohn's Disease Phenotypes in Southeastern Brazilians.Digestive diseases and sciences · 2016Article
- Neither self-reported ethnicity nor declared family origin are reliable indicators of genomic ancestry.Genetica · 2016Article
- Mitochondrial and genomic ancestry are associated with etiology of heart failure in Brazilian patients.Journal of human hypertension · 2016Article
- Assessment of IrisPlex-based multiplex for eye and skin color prediction with application to a Portuguese population.International journal of legal medicine · 2015Article
- The correlation between ancestry and color in two cities of Northeast Brazil with contrasting ethnic compositions.European journal of human genetics : EJHG · 2015Article
- Genomic analysis in the clinic: benefits and challenges for health care professionals and patients in Brazil.Journal of community genetics · 2015Article
- Genetic ancestry analysis in non-alcoholic fatty liver disease patients from Brazil and Portugal.World journal of hepatology · 2015Article
- Article
- Why personalized medicine will fail if we stay the course.Personalized medicine · 2012Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A current concern in genetic epidemiology studies in admixed populations is that population stratification can lead to spurious results. The Brazilian census classifies individuals according to self-reported "color", but several studies have demonstrated that stratifying according to "color" is not a useful strategy to control for population structure, due to the dissociation between self-reported "color" and genomic ancestry. We report the results of a study in a group of Brazilian siblings in which we measured skin pigmentation using a reflectometer, and estimated genomic ancestry using 21 Ancestry Informative Markers (AIMs). Self-reported "color", according to the Brazilian census, was also available for each participant. This made it possible to evaluate the relationship between self-reported "color" and skin pigmentation, self-reported "color" and genomic ancestry, and skin pigmentation and genomic ancestry. We observed that, although there were significant differences between the three "color" groups in genomic ancestry and skin pigmentation, there was considerable dispersion within each group and substantial overlap between groups. We also saw that there was no good agreement between the "color" categories reported by each member of the sibling pair: 30 out of 86 sibling pairs reported different "color", and in some cases, the sibling reporting the darker "color" category had lighter skin pigmentation. Socioeconomic status was significantly associated with self-reported "color" and genomic ancestry in this sample. This and other studies show that subjective classifications based on self-reported "color", such as the one that is used in the Brazilian census, are inadequate to describe the population structure present in recently admixed populations. Finally, we observed that one of the AIMs included in the panel (rs1426654), which is located in the known pigmentation gene SLC24A5, was strongly associated with skin pigmentation in this sample.
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