ArticlePloS one2011
A quorum-sensing factor in vegetative Dictyostelium discoideum cells revealed by quantitative migration analysis.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 37 citations in OpenAlex.
- Three-component contour dynamics model to simulate and analyze amoeboid cell motility in two dimensions.PloS one · 2024Article
- The aerotaxis ofFrontiers in cell and developmental biology · 2023Article
- On the origin of the functional versatility of macrophages.Frontiers in physiology · 2023Article
- Article
- Short- and long-term memory of moving amoeboid cells.PloS one · 2021Article
- Role of LrrkA in the Control of Phagocytosis and Cell Motility inFrontiers in cell and developmental biology · 2021Article
- From a discrete model of chemotaxis with volume-filling to a generalized Patlak-Keller-Segel model.Proceedings. Mathematical, physical, and engineering sciences · 2020Article
- Harnessing Motile Amoeboid Cells as Trucks for Microtransport and -Assembly.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2019Article
- Collective regulation of cell motility using an accurate density-sensing system.Journal of the Royal Society, Interface · 2018Article
- Modeling random crawling, membrane deformation and intracellular polarity of motile amoeboid cells.PloS one · 2018Article
- Synthetic quorum sensing in model microcapsule colonies.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Article
- Temperature limitation may explain the containment of the trophozoites in the cornea during Acanthamoeba castellanii keratitis.Parasitology research · 2014Article
- Quantitative and unbiased analysis of directional persistence in cell migration.Nature protocols · 2014Article
- Differential adhesion between moving particles as a mechanism for the evolution of social groups.PLoS computational biology · 2014Article
- Modeling and measuring signal relay in noisy directed migration of cell groups.PLoS computational biology · 2013Article
- A tapered channel microfluidic device for comprehensive cell adhesion analysis, using measurements of detachment kinetics and shear stress-dependent motion.Biomicrofluidics · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMany cells communicate through the production of diffusible signaling molecules that accumulate and once a critical concentration has been reached, can activate or repress a number of target genes in a process termed quorum sensing (QS). In the social amoeba Dictyostelium discoideum, QS plays an important role during development. However little is known about its effect on cell migration especially in the growth phase. METHODS AND
findingsTo investigate the role of cell density on cell migration in the growth phase, we use multisite timelapse microscopy and automated cell tracking. This analysis reveals a high heterogeneity within a given cell population, and the necessity to use large data sets to draw reliable conclusions on cell motion. In average, motion is persistent for short periods of time (t ≤ 5 min), but normal diffusive behavior is recovered over longer time periods. The persistence times are positively correlated with the migrated distances. Interestingly, the migrated distance decreases as well with cell density. The adaptation of cell migration to cell density highlights the role of a secreted quorum sensing factor (QSF) on cell migration. Using a simple model describing the balance between the rate of QSF generation and the rate of QSF dilution, we were able to gather all experimental results into a single master curve, showing a sharp cell transition between high and low motile behaviors with increasing QSF.
conclusionThis study unambiguously demonstrates the central role played by QSF on amoeboid motion in the growth phase.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.