ArticlePloS one2011
Designer TGFβ superfamily ligands with diversified functionality.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed.
- Comparison of the biocompatibility and osteogenesis potential of whitlockite and an activin A/BMP2 chimera using a rat calvarial defect model: a pilot study.Journal of periodontal & implant science · 2024Article
- The activin/BMP-2 chimera AB204 promotes periodontal tissue regeneration in a buccal dehiscence model: a pilot study.Journal of periodontal & implant science · 2024Article
- Bone regeneration using activin A/BMP2 chimera (AB204) with collagen membrane in rats with calvarial defects.Journal of periodontal & implant science · 2024Article
- Review
- Structural basis for ALK2/BMPR2 receptor complex signaling through kinase domain oligomerization.Nature communications · 2021Article
- Pien Tze Huang () Overcomes Doxorubicin Resistance and Inhibits Epithelial-Mesenchymal Transition in MCF-7/ADR Cells.Chinese journal of integrative medicine · 2019Article
- Activin A/BMP2 Chimera (AB204) Exhibits Better Spinal Bone Fusion Properties than rhBMP2.Journal of Korean Neurosurgical Society · 2018Article
- Impact of TGF-β family-related growth factors on chondrogenic differentiation of adipose-derived stem cells isolated from lipoaspirates and infrapatellar fat pads of osteoarthritic patients.European cells & materials · 2018Article
- Bone Morphogenetic Protein-Based Therapeutic Approaches.Cold Spring Harbor perspectives in biology · 2018Review
- Production, Isolation, and Structural Analysis of Ligands and Receptors of the TGF-β Superfamily.Methods in molecular biology (Clifton, N.J.) · 2016Article
- The effects of a single intravenous injection of novel activin A/BMP-2 (AB204) on toxicity and the respiratory and central nervous systems.Drug and chemical toxicology · 2016Article
- A Survey of Strategies to Modulate the Bone Morphogenetic Protein Signaling Pathway: Current and Future Perspectives.Stem cells international · 2016Review
- Activin A/BMP2 chimera AB235 drives efficient redifferentiation of long term cultured autologous chondrocytes.Scientific reports · 2015Article
- An activin A/BMP2 chimera, AB204, displays bone-healing properties superior to those of BMP2.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2014Article
- An Activin A/BMP2 chimera, AB215, blocks estrogen signaling via induction of ID proteins in breast cancer cells.BMC cancer · 2014Article
- MB109 as bioactive human bone morphogenetic protein-9 refolded and purified from E. coli inclusion bodies.Microbial cell factories · 2014Article
- Designer nodal/BMP2 chimeras mimic nodal signaling, promote chondrogenesis, and reveal a BMP2-like structure.The Journal of biological chemistry · 2014Article
- Pien Tze Huang Overcomes Multidrug Resistance and Epithelial-Mesenchymal Transition in Human Colorectal Carcinoma Cells via Suppression of TGF-β Pathway.Evidence-based complementary and alternative medicine : eCAM · 2014Article
- Reconstruction of radial bone defect using gelatin sponge and a BMP-2 combination graft.BMB reports · 2013Article
- Compound screening platform using human induced pluripotent stem cells to identify small molecules that promote chondrogenesis.Protein & cell · 2012Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transforming Growth Factor--beta (TGFβ) superfamily ligands, including Activins, Growth and Differentiation Factors (GDFs), and Bone Morphogenetic Proteins (BMPs), are excellent targets for protein-based therapeutics because of their pervasiveness in numerous developmental and cellular processes. We developed a strategy termed RASCH (Random Assembly of Segmental Chimera and Heteromer), to engineer chemically-refoldable TGFβ superfamily ligands with unique signaling properties. One of these engineered ligands, AB208, created from Activin-βA and BMP-2 sequences, exhibits the refolding characteristics of BMP-2 while possessing Activin-like signaling attributes. Further, we find several additional ligands, AB204, AB211, and AB215, which initiate the intracellular Smad1-mediated signaling pathways more strongly than BMP-2 but show no sensitivity to the natural BMP antagonist Noggin unlike natural BMP-2. In another design, incorporation of a short N-terminal segment from BMP-2 was sufficient to enable chemical refolding of BMP-9, without which was never produced nor refolded. Our studies show that the RASCH strategy enables us to expand the functional repertoire of TGFβ superfamily ligands through development of novel chimeric TGFβ ligands with diverse biological and clinical values.
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Registered trials
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