ArticlePloS one2011
Autonomic modulation and health-related quality of life among schizophrenic patients treated with non-intensive case management.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Autonomic nervous system dysfunction in psychiatric disorders and the impact of psychotropic medications: a systematic review and meta-analysis.Journal of psychiatry & neuroscience : JPN · 2016Pooled it
- Association between health-related quality of life and heart rate variability in elderly individuals with cognitive impairment in Korea: cross-sectional study.BMC geriatrics · 2023Article
- FABP3, FABP4, and heart rate variability among patients with chronic schizophrenia.Frontiers in endocrinology · 2023Article
- Blunted pupil light reflex is associated with negative symptoms and working memory in individuals with schizophrenia.Schizophrenia research · 2022Article
- Poorer Well-Being in Children With Misophonia: Evidence From theFrontiers in psychology · 2022Article
- Heart Rate Variability in Schizophrenia and Autism.Frontiers in psychiatry · 2021Article
- Influence of Acute Antipsychotic Treatment on Cardiorespiratory Coupling and Heart Rate Variability.Cureus · 2018Article
- Correlation between health-related quality of life in the physical domain and heart rate variability in asymptomatic adults.Health and quality of life outcomes · 2016Article
- The assessment of quality of life in clinical practice in patients with schizophrenia.Dialogues in clinical neuroscience · 2014Article
- Self-reported psychopathology and health-related quality of life in heroin users treated with methadone.Neuropsychiatric disease and treatment · 2013Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSchizophrenia is associated with autonomic dysfunction and this may increase cardiovascular mortality. Past studies on autonomic modulation of schizophrenic patients focused on inpatients rather than individuals in a community setting, especially those receiving non-intensive case management (non-ICM). Besides, autonomic modulation and its association with health-related quality of life (HRQoL) in this population remain unexplored.
methodsA total of 25 schizophrenic patients treated by non-ICM and 40 healthy volunteers were matched by age, gender and body mass index; smokers were excluded. Between the two groups, we compared the individuals' 5 min resting assessments of heart rate variability and their HRQoL, which was measured using EuroQoL-5D (EQ-5D). Patients with schizophrenia were assessed for psychopathology using the Positive and Negative Syndrome Scale for Schizophrenia (PANSS). We examined the relationship between heart rate variability measurements, HRQoL scores, PANSS scores, and other clinical variables among the schizophrenic patients treated by non-ICM.
resultsCompared to the controls, patients with schizophrenia showed a significant impairment of autonomic modulation and a worse HRQoL. Cardiovagal dysfunction among the schizophrenic patients could be predicted independently based on lower educational level and more negative symptoms. Sympathetic predominance was directly associated with anticholinergics use and EQ-5D using a visual analogue scale (EQ-VAS).
conclusionPatients with schizophrenia treated by non-ICM show a significant impairment of their autonomic function and HRQoL compared to the controls. Since the sympathovagal dysfunction is associated with more negative symptoms or higher VAS score, the treatment of the negative symptoms as well as the monitoring of HRQoL might help to manage cardiovascular risk among these individuals. In addition, EQ-VAS scores must be interpreted more cautiously in such a population.
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