ArticlePloS one2011
Drosophila TRPA channel painless inhibits male-male courtship behavior through modulating olfactory sensation.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 29 citations in OpenAlex.
- Nutritional Trade-Offs inBiology · 2025Article
- The non-nuclear DifB NF-κB isoform affects courtship, circadian, and locomotor behavior in adultFrontiers in behavioral neuroscience · 2025Article
- Review
- Article
- Intense light unleashes male-male courtship behaviour in wild-typeOpen biology · 2023Article
- Alleviation of thermal nociception depends on heat-sensitive neurons and a TRP channel in the brain.Current biology : CB · 2023Article
- Myc suppresses male-male courtship in Drosophila.The EMBO journal · 2022Article
- Review
- Single cell transcriptomes reveal expression patterns of chemoreceptor genes in olfactory sensory neurons of the Caribbean spiny lobster, Panulirus argus.BMC genomics · 2020Article
- A Model for Basic Emotions Using Observations of Behavior inFrontiers in psychology · 2019Review
- Article
- UsingFrontiers in cellular neuroscience · 2018Review
- TRPA1 expression and its functional activation in rodent cortex.Open biology · 2017Article
- TRPA5, an Ankyrin Subfamily Insect TRP Channel, is Expressed in Antennae of Cydia pomonella (Lepidoptera: Tortricidae) in Multiple Splice Variants.Journal of insect science (Online) · 2016Article
- Insulin-producing cells regulate the sexual receptivity through the painless TRP channel in Drosophila virgin females.PloS one · 2014Article
- Modulation of innate and learned sexual behaviors by the TRP channel Painless expressed in the fruit fly brain: behavioral genetic analysis and its implications.Frontiers in behavioral neuroscience · 2014Review
- Evolutionarily conserved, multitasking TRP channels: lessons from worms and flies.Handbook of experimental pharmacology · 2014Article
- The transient receptor potential channel TRPA1: from gene to pathophysiology.Pflugers Archiv : European journal of physiology · 2012Review
- Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Drosophila melanogaster TRPA family member painless, expressed in a subset of multidendritic neurons embeding in the larval epidermis, is necessary for larval nociception of noxious heat or mechanical stimuli. However, the function of painless in adult flies remains largely unknown. Here we report that mutation of painless leads to a defect in male-male courtship behavior and alteration in olfaction sensitivity in adult flies. Specific downregulation of the expression of the Painless protein in the olfactory projection neurons (PNs) of the antennal lobes (ALs) resulted in a phenotype resembling that found in painless mutant flies, whereas overexpression of Painless in PNs of painless mutant males suppressed male-male courtship behavior. The downregulation of Painless exclusively during adulthood also resulted in male-male courtship behavior. In addition, mutation of the painless gene in flies caused changes in olfaction, suggesting a role for this gene in olfactory processing. These results indicate that functions of painless in the adult central nervous system of Drosophila include modulation of olfactory processing and inhibition of male-male courtship behavior.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.