ArticleFrontiers in behavioral neuroscience2011
Dysregulated mTORC1-Dependent Translational Control: From Brain Disorders to Psychoactive Drugs.
Article in Frontiers in behavioral neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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Who cites it
18 citing papers in PubMed.
- PTEN Subcellular Localization Dictates Function.bioRxiv : the preprint server for biology · 2026Article
- Overactive Neuronal eEF2K/eEF2 signaling is associated with cognitive impairment and apathy-like behavior.Molecular psychiatry · 2026Article
- Exploring the dynamics of messenger ribonucleoprotein-mediated translation repression.Biochemical Society transactions · 2024Review
- A perspective on molecular signalling dysfunction, its clinical relevance and therapeutics in autism spectrum disorder.Experimental brain research · 2022Review
- Dynamic RNA Regulation in the Brain Underlies Physiological Plasticity in a Hibernating Mammal.Frontiers in physiology · 2020Article
- D1 Dopamine Receptor Activation Induces Neuronal eEF2 Pathway-Dependent Protein Synthesis.Frontiers in molecular neuroscience · 2020Article
- mTORC1 Is a Local, Postsynaptic Voltage Sensor Regulated by Positive and Negative Feedback Pathways.Frontiers in cellular neuroscience · 2017Article
- Current Perspectives in Autism Spectrum Disorder: From Genes to Therapy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Review
- Pushing the threshold: How NMDAR antagonists induce homeostasis through protein synthesis to remedy depression.Brain research · 2016Review
- Analysis of Proteins That Rapidly Change Upon Mechanistic/Mammalian Target of Rapamycin Complex 1 (mTORC1) Repression Identifies Parkinson Protein 7 (PARK7) as a Novel Protein Aberrantly Expressed in Tuberous Sclerosis Complex (TSC).Molecular & cellular proteomics : MCP · 2016Article
- Expression and function of ryanodine receptor related pathways in PCB tolerant Atlantic killifish (Fundulus heteroclitus) from New Bedford Harbor, MA, USA.Aquatic toxicology (Amsterdam, Netherlands) · 2015Article
- Decreased mTOR signaling pathway in human idiopathic autism and in rats exposed to valproic acid.Acta neuropathologica communications · 2015Article
- Genetic or pharmacological reduction of PERK enhances cortical-dependent taste learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Antipsychotics activate mTORC1-dependent translation to enhance neuronal morphological complexity.Science signaling · 2014Article
- Brain-specific disruption of the eIF2α kinase PERK decreases ATF4 expression and impairs behavioral flexibility.Cell reports · 2012Article
- Neuronal signaling and behavior.Frontiers in behavioral neuroscience · 2012Article
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Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the last decade, a plethora of studies utilizing pharmacological, biochemical, and genetic approaches have shown that precise translational control is required for long-lasting synaptic plasticity and the formation of long-term memory. Moreover, more recent studies indicate that alterations in translational control are a common pathophysiological feature of human neurological disorders, including developmental disorders, neuropsychiatric disorders, and neurodegenerative diseases. Finally, translational control mechanisms are susceptible to modification by psychoactive drugs. Taken together, these findings point to a central role for translational control in the regulation of synaptic function and behavior.
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Registered trials
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