ArticleInternational journal of molecular sciences2011
Candida colonization index in patients admitted to an ICU.
Article in International journal of molecular sciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
- Oral nystatin prophylaxis in surgical/trauma ICU patients: a randomised clinical trial.Critical care (London, England) · 2012Trial
- Overview of Risk Factors and Diagnosis of Invasive Candidiasis.Journal of fungi (Basel, Switzerland) · 2026Review
- Low Colonisation Rate of Candida auris in Patients of Intensive Care Units: A Study From Central India.Cureus · 2025Article
- Early-Onset Candidemia in Adult Intensive Care Units.Diagnostics (Basel, Switzerland) · 2025Review
- Isolation ofJournal of fungi (Basel, Switzerland) · 2024Article
- Insights intoJournal of fungi (Basel, Switzerland) · 2024Article
- Comparison of Candida colonization in intensive care unit patients with and without COVID-19: First prospective cohort study from Turkey.Medical mycology · 2024Article
- High frequency ofCurrent medical mycology · 2022Article
- Screening forEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2021Article
- Evaluation of a Novel Laboratory Candiduria Screening Protocol in the Intensive Care Unit.Infection and drug resistance · 2021Article
- Prevalence, species distribution, and risk factors of fungal colonization and infection in patients at a burn intensive care unit in Vietnam.Current medical mycology · 2020Article
- Candiduria; a review article with specific data from Iran.Turkish journal of urology · 2018Review
- What has changed in the treatment of invasive candidiasis? A look at the past 10 years and ahead.The Journal of antimicrobial chemotherapy · 2018Review
- Antifungal susceptibility patterns of colonizedIranian journal of microbiology · 2017Article
- Invasive Candida Infections in the ICU: Diagnosis and Therapy.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2015Review
- Invasive Candida infections in patients of a medical intensive care unit: attempt of improving diagnosis by quantifying the colonization.Wiener klinische Wochenschrift · 2015Observational
- Candida colonization index and subsequent infection in critically ill surgical patients: 20 years later.Intensive care medicine · 2014Review
- A survey on infection management practices in Italian ICUs.Critical care (London, England) · 2012Article
- A tool kit for quantifying eukaryotic rRNA gene sequences from human microbiome samples.Genome biology · 2012Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multiple-site colonization with Candida spp. is commonly recognized as a risk factor for invasive fungal infection in critically ill patients. We carried out a study to determine the relationship between Candida colonization and invasive infection in neurological patients admitted to an ICU. At admission (T0) and every three days for two weeks, different samples (pharynx swab, tracheal secretions, stomach contents, etc.) were collected for mycological surveillance. Candida mannan antigen and Candida anti-mannan antibodies were assayed. The Colonization Index (CI) and Corrected Colonization Index were calculated for each time point. Of all patients 70% was already colonized by Candida spp. at T0 and six of them had CI ≥ 0.5. Three patients developed candidemia; they had CI ≥ 0.5 before infection. Positive values of Candida mannan antigen and anti-mannan antibodies were found only in the patients with candidemia. The sensitivity and specificity of the Candida mannan test were 66.6% and 100%, respectively, while the sensitivity and specificity of the anti-mannan antibody test were 100%. In accordance with other authors, we find the surveillance cultures are useful to monitor the Candida colonization in ICU patients. In addition, the sequential observation of anti-mannan antibodies could contribute to early diagnosis of candidiasis more than Candida mannan antigen in immunocompetent patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.