ArticleInternational journal of molecular sciences2011
Characterization of terpenoids from the root of Ceriops tagal with antifouling activity.
Article in International journal of molecular sciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 26 citations in OpenAlex.
- Ethnopharmacology, Phytochemistry, and Global Distribution of Mangroves-A Comprehensive Review.Marine drugs · 2019Review
- Anti-quorum sensing potential of the mangrove Rhizophora annamalayana.World journal of microbiology & biotechnology · 2013Article
- New acetylenic derivatives of betulin and betulone, synthesis and cytotoxic activity.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agentsReview
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
One new dimeric diterpenoid, 8(14)-enyl-pimar-2'(3')-en-4'(18')-en-15'(16')-endolabr- 16,15,2',3'-oxoan-16-one (1) and five known terpenoids: Tagalsin C (2), Tagalsin I (3), lup-20(29)-ene-3β,28-diol (4), 3-oxolup-20(29)-en-28-oic acid (5) and 28-hydroxylup- 20(29)-en-3-one (6) were isolated from the roots of the mangrove plant Ceriops tagal. Their structures and relative stereochemistry were elucidated by means of extensive NMR, IR and MS analysis. The antifouling activity against larval settlement of the barnacle Balanus albicostatus were evaluated using capsaicin as a positive control. All these terpenoids exhibited antifouling activity against cyprid larvae of the barnacle without significant toxicity. The structure-activity relationship results demonstrated that the order of antifouling activity was diterpenoid (Compound 2) > triterpenoid (Compounds 4, 5 and 6) > dimeric diterpenoid (Compounds 1 and 3). The functional groups on the C-28 position of lupane triterpenoid significantly affect the antifouling activity. The diterpenoid dimmer with two identical diterpenoid subunits might display more potent antifouling activity than one with two different diterpenoid subunits. The stability test showed that Compounds 2, 4, 5 and 6 remained stable over 2-month exposure under filtered seawater.
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