ArticleInternational journal of nanomedicine2011
Anticancer efficacy enhancement and attenuation of side effects of doxorubicin with titanium dioxide nanoparticles.
Article in International journal of nanomedicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed, 145 citations in OpenAlex.
- Multifaceted biomedical applications of biogenic titanium dioxide nanoparticles fabricated by marine actinobacterium Streptomyces vinaceusdrappus AMG31.Scientific reports · 2025Article
- Titanium nanostructure mitigating doxorubicin-induced testicular toxicity in rats via regulating major autophagy signaling pathways.Toxicology reports · 2025Article
- Organocyclophosphazenes and Materials Based on Them for Pharmaceuticals and Biomedicine.Biomolecules · 2025Review
- Unlocking the potential of titanium dioxide nanoparticles: an insight into green synthesis, optimizations, characterizations, and multifunctional applications.Microbial cell factories · 2024Review
- Article
- Alleviation of doxorubicin adverse effects via loading into various drug-delivery systems: a comparative study.Therapeutic delivery · 2024Article
- Hybrid Nanoparticle-Assisted Chemo-Photothermal Therapy and Photoacoustic Imaging in a Three-Dimensional Breast Cancer Cell Model.International journal of molecular sciences · 2023Article
- Bioorthogonal activation of prodrugs, for the potential treatment of breast cancer, using the Staudinger reaction.RSC medicinal chemistry · 2023Article
- Green Synthesised TiOMolecules (Basel, Switzerland) · 2023Article
- Pharmacodynamic Material Basis and Potential Mechanism Study of Spatholobi Caulis in Reversing Osteoporosis.Evidence-based complementary and alternative medicine : eCAM · 2023Article
- Engineered titania nanomaterials in advanced clinical applications.Beilstein journal of nanotechnology · 2022Review
- Metal-based nano-delivery platform for treating bone disease and regeneration.Frontiers in chemistry · 2022Review
- Breast Cancer Inhibition by Biosynthesized Titanium Dioxide Nanoparticles Is Comparable to Free Doxorubicin but Appeared Safer in BALB/c Mice.Materials (Basel, Switzerland) · 2021Article
- Article
- The emerging therapeutic role of mesenchymal stem cells in anthracycline-induced cardiotoxicity.Cell and tissue research · 2021Review
- Encapsulation of Hydrophobic Drugs in Shell-by-Shell Coated Nanoparticles for Radio-and Chemotherapy-An In Vitro Study.Bioengineering (Basel, Switzerland) · 2020Article
- Poly (I:C)- and doxorubicin-loaded magnetic dendrimeric nanoparticles affect the apoptosis-related gene expressions in MCF-7 cells.Turkish journal of biology = Turk biyoloji dergisi · 2020Article
- Size Matters in the Cytotoxicity of Polydopamine Nanoparticles in Different Types of Tumors.Cancers · 2019Article
- Targeting autophagy using metallic nanoparticles: a promising strategy for cancer treatment.Cellular and molecular life sciences : CMLS · 2019Review
- Discovery of Novel Doxorubicin Metabolites in MCF7 Doxorubicin-Resistant Cells.Frontiers in pharmacology · 2019Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDoxorubicin has a broad spectrum of anticancer activity, but its clinical application is limited due to serious side effects. The aim of this study was to explore a novel drug delivery system based on titanium dioxide (TiO(2)) nanoparticles for its potential role in enhancing the anticancer efficacy of doxorubicin while reducing its side effects. METHODS AND
resultsDoxorubicin was loaded into TiO(2) nanoparticles by forming complexes with the transition metal, titanium, to construct doxorubicin-titanium dioxide (DOX-TiO(2)) nanocomposites as a drug delivery system. The anticancer activity of the DOX-TiO(2) nanocomposites was demonstrated by MTT assay, and the possible signaling pathway was explored by Western blot. In human SMMC-7721 hepatocarcinoma cells, our observations demonstrated that this drug delivery system markedly increased the efficiency of drug per dosage and decreased the IC(50), resulting in anticancer efficacy enhancement and side effect attenuation.
conclusionSuch a doxorubicin delivery strategy is promising in cancer therapy. Apoptosis may contribute to the mechanism, due to protein expression of Bcl-2 being downregulated and that of Bax and caspase 3 being upregulated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.