ArticleJournal of virology2012
Impact of host proteases on reovirus infection in the respiratory tract.
Article in Journal of virology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 30 citations in OpenAlex.
- Host Cell Proteases Involved in Human Respiratory Viral Infections and Their Inhibitors: A Review.Viruses · 2024Review
- Evolutionary history of type II transmembrane serine proteases involved in viral priming.Human genetics · 2022Article
- Host serine proteases TMPRSS2 and TMPRSS11D mediate proteolytic activation and trypsin-independent infection in group A rotaviruses.Journal of virology · 2021Article
- Control of Capsid Transformations during Reovirus Entry.Viruses · 2021Review
- Article
- Protein Mismatches Caused by Reassortment Influence Functions of the Reovirus Capsid.Journal of virology · 2018Article
- Lipids Cooperate with the Reovirus Membrane Penetration Peptide to Facilitate Particle Uncoating.The Journal of biological chemistry · 2016Article
- Cell Surface Human Airway Trypsin-Like Protease Is Lost During Squamous Cell Carcinogenesis.Journal of cellular physiology · 2016Article
- Lipid Membranes Facilitate Conformational Changes Required for Reovirus Cell Entry.Journal of virology · 2015Article
- Potential for Improving Potency and Specificity of Reovirus Oncolysis with Next-Generation Reovirus Variants.Viruses · 2015Review
- Article
- Mammalian orthoreovirus T3D infects U-118 MG cell spheroids independent of junction adhesion molecule-A.Gene therapy · 2014Article
- HATL5: a cell surface serine protease differentially expressed in epithelial cancers.PloS one · 2014Article
- The μ1 72-96 loop controls conformational transitions during reovirus cell entry.Journal of virology · 2013Article
- Genetic determinants of reovirus pathogenesis in a murine model of respiratory infection.Journal of virology · 2013Article
- Respiratory infection of mice with mammalian reoviruses causes systemic infection with age and strain dependent pneumonia and encephalitis.Virology journal · 2013Article
- Reovirus receptors, cell entry, and proapoptotic signaling.Advances in experimental medicine and biology · 2013Review
- Mechanisms of reovirus bloodstream dissemination.Advances in virus research · 2013Review
- Cell entry-associated conformational changes in reovirus particles are controlled by host protease activity.Journal of virology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Virion uncoating is an essential early event in reovirus infection. In natural enteric infections, rapid proteolytic uncoating of virions is mediated by pancreatic serine proteases. The proteases that promote reovirus disassembly and cell entry in the respiratory tract remain unknown. In this report, we show that endogenous respiratory and inflammatory proteases can promote reovirus infection in vitro and that preexisting inflammation augments in vivo infection in the murine respiratory tract.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.