ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2011
Dendritic spine dynamics regulate the long-term stability of synaptic plasticity.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 82 citations in OpenAlex.
- mPFC hemorrhage induces hippocampal CA1 dendritic spine plasticity and attentional deficits in mice.Research in pharmaceutical sciences · 2026Article
- MiR-30a-5p mediates epileptogenesis in epilepsy models by targeting SOX4 to regulate the Wnt/β-catenin pathway.Epilepsia open · 2026Article
- Dendritic heterosynaptic plasticity arises from calcium-based input learning.Communications biology · 2026Article
- Plastic Arbor: A modern simulation framework for synaptic plasticity-From single synapses to networks of morphological neurons.PLoS computational biology · 2026Article
- Synaptic micromechanics and brain softening as a mechanobiological hypothesis for Alzheimer's disease.Frontiers in neuroscience · 2026Article
- Calcium dynamics in small spaces: Lessons learned from modeling in dendritic spines.Biophysical journal · 2025Review
- Age-related loss of large dendritic spines in the precuneus is statistically mediated by proteins which are predicted targets of existing drugs.Molecular psychiatry · 2025Article
- The Dose-Dependent Effects of Fluorocitrate on the Metabolism and Activity of Astrocytes and Neurons.Brain sciences · 2025Article
- Bidirectional Effect of Long-Term ΔACS pharmacology & translational science · 2024Article
- Linking spontaneous and stimulated spine dynamics.Communications biology · 2023Article
- Article
- Fmr1-KO mice failure to detect object novelty associates with a post-test decrease of structural and synaptic plasticity upstream of the hippocampus.Scientific reports · 2023Article
- Altered integration of excitatory inputs onto the basal dendrites of layer 5 pyramidal neurons in a mouse model of Fragile X syndrome.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Antidepressant-like effects of theFrontiers in pharmacology · 2023Article
- Adaptive control of synaptic plasticity integrates micro- and macroscopic network function.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Review
- From synapses to circuits and back: Bridging levels of understanding in animal models of Alzheimer's disease.The European journal of neuroscience · 2022Review
- Dendritic spine morphology regulates calcium-dependent synaptic weight change.The Journal of general physiology · 2022Article
- Autoregulation of switching behavior by cellular compartment size.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Memory retention in pyramidal neurons: a unified model of energy-based homo and heterosynaptic plasticity with homeostasis.Cognitive neurodynamics · 2021Article
- PSD-95 in CA1 Area Regulates Spatial Choice Depending on Age.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Long-term synaptic plasticity requires postsynaptic influx of Ca²⁺ and is accompanied by changes in dendritic spine size. Unless Ca²⁺ influx mechanisms and spine volume scale proportionally, changes in spine size will modify spine Ca²⁺ concentrations during subsequent synaptic activation. We show that the relationship between Ca²⁺ influx and spine volume is a fundamental determinant of synaptic stability. If Ca²⁺ influx is undercompensated for increases in spine size, then strong synapses are stabilized and synaptic strength distributions have a single peak. In contrast, overcompensation of Ca²⁺ influx leads to binary, persistent synaptic strengths with double-peaked distributions. Biophysical simulations predict that CA1 pyramidal neuron spines are undercompensating. This unifies experimental findings that weak synapses are more plastic than strong synapses, that synaptic strengths are unimodally distributed, and that potentiation saturates for a given stimulus strength. We conclude that structural plasticity provides a simple, local, and general mechanism that allows dendritic spines to foster both rapid memory formation and persistent memory storage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.