ReviewThe Journal of neuroscience : the official journal of the Society for Neuroscience2011
Large-scale automated histology in the pursuit of connectomes.
Review in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers.
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Who cites it
90 citing papers in PubMed.
- Fluorescent Labeling Methods for Brain Structure Research.Molecules (Basel, Switzerland) · 2026Review
- WASPSYN: A Challenge for Domain Adaptive Synapse Detection in Microwasp Brain Connectomes.IEEE transactions on medical imaging · 2024Article
- Hierarchical communities in the larvalProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Volume electron microscopy analysis of synapses in primary regions of the human cerebral cortex.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Tracing nerve fibers with volume electron microscopy to quantitatively analyze brain connectivity.Communications biology · 2024Article
- Permittivity tensor imaging: modular label-free imaging of 3D dry mass and 3D orientation at high resolution.Nature methods · 2024Article
- Bringing synapses into focus: Recent advances in synaptic imaging and mass-spectrometry for studying synaptopathy.Frontiers in synaptic neuroscience · 2023Review
- Array tomography: 15 years of synaptic analysis.Neuronal signaling · 2022Article
- A Molecular Landscape of Mouse Hippocampal Neuromodulation.Frontiers in neural circuits · 2022Article
- High-throughput mapping of a whole rhesus monkey brain at micrometer resolution.Nature biotechnology · 2021Article
- Identification of the suprachiasmatic nucleus venous portal system in the mammalian brain.Nature communications · 2021Article
- Three-Dimensional Synaptic Organization of Layer III of the Human Temporal Neocortex.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
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- Relating network connectivity to dynamics: opportunities and challenges for theoretical neuroscience.Current opinion in neurobiology · 2019Review
- Scalable volumetric imaging for ultrahigh-speed brain mapping at synaptic resolution.National science review · 2019Article
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- A null model of the mouse whole-neocortex micro-connectome.Nature communications · 2019Article
- Dimensionality in recurrent spiking networks: Global trends in activity and local origins in connectivity.PLoS computational biology · 2019Article
- Synchronization dependent on spatial structures of a mesoscopic whole-brain network.PLoS computational biology · 2019Article
30 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
19 authors.
Funding
Abstract
How does the brain compute? Answering this question necessitates neuronal connectomes, annotated graphs of all synaptic connections within defined brain areas. Further, understanding the energetics of the brain's computations requires vascular graphs. The assembly of a connectome requires sensitive hardware tools to measure neuronal and neurovascular features in all three dimensions, as well as software and machine learning for data analysis and visualization. We present the state of the art on the reconstruction of circuits and vasculature that link brain anatomy and function. Analysis at the scale of tens of nanometers yields connections between identified neurons, while analysis at the micrometer scale yields probabilistic rules of connection between neurons and exact vascular connectivity.
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Registered trials
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