Evidence map›Paper›PMID 22072664›Full record

ReviewThe Journal of neuroscience : the official journal of the Society for Neuroscience2011

The placebo effect: advances from different methodological approaches.

Karin Meissner, Ulrike Bingel, Luana Colloca, Tor D Wager, Alison Watson, Magne Arve Flaten

4 registry-linked trialsAbstract readReview
In one paragraph

Review in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 61 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02473185 phase4completednot on this mapstarted 2015, after this paper: background citation

Effects of Expectation, Medication and Placebo on Objective and Self-rated Performance During the Quantified Behavior Test in Patients With Untreated ADHD

TypeinterventionalSponsorRegion VästmanlandRan2015 to 2018Enrolled40ConditionsAttention Deficit Hyperactivity DisorderArmsMethylphenidate
NCT02477280 phase4completednot on this mapstarted 2016, after this paper: background citation

Effects of Expectation, Medication and Placebo on Objective and Self-rated Performance During the Quantified Behavior Test in Patients With Untreated ADHD and Substance Use Disorder

TypeinterventionalSponsorRegion VästmanlandRan2016 to 2021Enrolled39ConditionsAttention Deficit Hyperactivity Disorder, Substance Use DisorderArmsMethylphenidate, Placebo
NCT03629288 nacompletednot on this mapstarted 2016, after this paper: background citation

Clinical and Microbiological Efficacy of a Azithromycin as an Adjunct to Non-Surgical Periodontal Treatment : A Randomized Controlled Clinical Trial

TypeinterventionalSponsorUniversidad Nacional Andres BelloRan2016 to 2016Enrolled18ConditionsPeriodontitisArmsLactose tab, Azithromycin
NCT04389931 nacompletednot on this mapstarted 2016, after this paper: background citation

Effect of Omega 3 as an Immunomodulator Adjunct to Periodontal Debridement: A Randomized Controlled Clinical Trial

TypeinterventionalSponsorUniversidad Nacional Andres BelloRan2016 to 2016Enrolled18ConditionsPeriodontitisArmsLactose tab, Omega 3
3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Trial
  8. Trial
  9. Trial
  10. Trial
  11. Trial
  12. Trial
  13. Trial
  14. Trial
  15. Frontal-Brainstem Pathways Mediating Placebo Effects on Social Rejection.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017
    Trial
  16. Trial
  17. Trial
  18. Trial
  19. Trial
  20. Trial

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Karin MeissnerInstitute of Medical Psychology, Ludwig-Maximilians-University of Munich, D-80336 Munich, Germany.
Ulrike Bingel
Luana Colloca
Tor D Wager
Alison Watson
Magne Arve Flaten

Funding

The Neural Bases of Placebo Effects and their Relation to Regulatory ProcessesR01MH076136 · NIMH · UNIVERSITY OF COLORADO · PI WAGER, TOR D. · 2007 to 2023
$8.5M
Mechanisms of pain and placebo analgesiaZIAAT000019 · NCCIH · NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH · PI GRILLON, CHRISTIAN · 2012 to 2014
$1.3M
Neuroimaging-based biomarkers for two components of painRC1DA028608 · NIDA · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI SMITH, EDWARD E. · 2009 to 2010
$999k
Intramural NIH HHS Z99 AT999999NIDA NIH HHS 1RC1DA028608NIDA NIH HHS RC1 DA028608NIMH NIH HHS R01 MH076136NIMH NIH HHS R01MH076136
6 · The paper itself

Abstract

There is accumulating evidence from different methodological approaches that the placebo effect is a neurobiological phenomenon. Behavioral, psychophysiological, and neuroimaging results have largely contributed to accepting the placebo response as real. A major aspect of recent and future advances in placebo research is to demonstrate linkages between behavior, brain, and bodily responses. This article provides an overview of the processes involved in the formation of placebo responses by combining research findings from behavioral, psychophysiological, and neuroimaging methods. The integration of these different methodological approaches is a key objective, motivating our scientific pursuits toward a placebo research that can inform and guide important future scientific knowledge.

Indexed as

Placebo EffectPsychophysiologyAutonomic Nervous SystemBrainClinical Trials as TopicHumansNervous System DiseasesNeuroimagingPlacebosPlacebos

Identifiers

PMID22072664
PMCPMC3242469

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.