ArticleJournal of muscle research and cell motility2012
Non-crossbridge calcium-dependent stiffness in slow and fast skeletal fibres from mouse muscle.
Article in Journal of muscle research and cell motility, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 25 citations in OpenAlex.
- How temperature tunes muscle mechanics during eccentric contractions.American journal of physiology. Cell physiology · 2026Article
- Titin activates myosin filaments in skeletal muscle by switching from an extensible spring to a mechanical rectifier.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- The Effects of Isometric Fatigue on Trunk Muscle Stiffness: Implications for Shear-Wave Elastography Measurements.Sensors (Basel, Switzerland) · 2022Article
- Mechanisms of Frank-Starling law of the heart and stretch activation in striated muscles may have a common molecular origin.Journal of muscle research and cell motility · 2021Article
- The effects of a skeletal muscle titin mutation on walking in mice.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2017Article
- The increase in non-cross-bridge forces after stretch of activated striated muscle is related to titin isoforms.American journal of physiology. Cell physiology · 2016Article
- Non-crossbridge forces in activated striated muscles: a titin dependent mechanism of regulation?Journal of muscle research and cell motility · 2015Review
- Mechanism of force enhancement during stretching of skeletal muscle fibres investigated by high time-resolved stiffness measurements.Journal of muscle research and cell motility · 2013Article
- Effect of temperature on crossbridge force changes during fatigue and recovery in intact mouse muscle fibers.PloS one · 2013Article
- Residual force enhancement in skeletal muscles: one sarcomere after the other.Journal of muscle research and cell motility · 2012Review
- The mechanisms of the residual force enhancement after stretch of skeletal muscle: non-uniformity in half-sarcomeres and stiffness of titin.Proceedings. Biological sciences · 2012Review
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We showed previously that force development in frog and FDB mouse skeletal muscle fibres is preceded by an increase of fibre stiffness occurring well before crossbridge attachment and force generation. This stiffness increase, referred to as static stiffness, is due to a Ca(2+)-dependent stiffening of a non-crossbridge sarcomere structure which we suggested could be attributed to the titin filaments. To investigate further the role of titin in static stiffness, we measured static stiffness properties at 24 and 35°C in soleus and EDL mouse muscle fibres which are known to express different titin isoforms. We found that static stiffness was present in both soleus and EDL fibres, however, its value was about five times greater in EDL than in soleus fibres. The rate of development of static stiffness on stimulation increased with temperature and was slightly faster in EDL than in soleus in agreement with previously published data on the time course of the intracellular Ca(2+) transients in these muscles. The present results show that the presence of a non-crossbridge Ca(2+)-dependent stiffening of the muscle fibre is a physiological general characteristic of skeletal muscle. Static stiffness depends on fibre type, being greater and developing faster in fast than in slow fibres. Our observations are consistent with the idea that titin stiffening on contraction improves the sarcomere structure stability. Such an action in fact seems to be more important in EDL fast fibre than in soleus slow fibres.
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