ArticleExtremophiles : life under extreme conditions2012
Leishmanicidal and antitumoral activities of endophytic fungi associated with the Antarctic angiosperms Deschampsia antarctica Desv. and Colobanthus quitensis (Kunth) Bartl.
Article in Extremophiles : life under extreme conditions, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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36 citing papers in PubMed, 92 citations in OpenAlex.
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- Diversity and enzymatic, biosurfactant and phytotoxic activities of culturable Ascomycota fungi present in marine sediments obtained near the South Shetland Islands, maritime Antarctica.Extremophiles : life under extreme conditions · 2024Article
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- Cryptic fungal diversity revealed by DNA metabarcoding in historic wooden structures at Whalers Bay, Deception Island, maritime Antarctic.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2023Article
- Commonalities between the Atacama Desert and Antarctica rhizosphere microbial communities.Frontiers in microbiology · 2023Article
- Two New Species and a New Record ofJournal of fungi (Basel, Switzerland) · 2022Article
- Biodiversity and Bioprospecting of Fungal Endophytes from the Antarctic PlantJournal of fungi (Basel, Switzerland) · 2022Article
- Ecology and potential functions of plant-associated microbial communities in cold environments.FEMS microbiology ecology · 2022Review
- DNA Metabarcoding to Assess the Diversity of Airborne Fungi Present over Keller Peninsula, King George Island, Antarctica.Microbial ecology · 2021Article
- Anti-leishmanial and anti-trypanosomal natural products from endophytes.Parasitology research · 2021Review
- Screening and Genetic Network Analysis of Genes Involved in Freezing and Thawing Resistance inGenes · 2021Article
- Description of the First Four Species of the GenusFrontiers in microbiology · 2021Article
- Response of psychrophilic plant endosymbionts to experimental temperature increase.Royal Society open science · 2020Article
- Extracellular Enzymes and Bioactive Compounds from Antarctic Terrestrial Fungi for Bioprospecting.International journal of environmental research and public health · 2020Review
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A total of 564 isolates of endophytic fungi were recovered from the plants Deschampsia antarctica and Colobanthus quitensis collected from Antarctica. The isolates were screened against parasites Leishmania amazonensis and Trypanosoma cruzi and against the human tumour cell lines. Of the 313 fungal isolates obtained from D. antarctica and 251 from C. quitensis, 25 displayed biological activity. Nineteen extracts displayed leishmanicidal activity, and six inhibited the growth of at least one tumour cell line. These fungi belong to 19 taxa of the genera Alternaria, Antarctomyces, Cadophora, Davidiella, Helgardia, Herpotrichia, Microdochium, Oculimacula, Phaeosphaeria and one unidentified fungus. Extracts of 12 fungal isolates inhibited the proliferation of L. amazonesis at a low IC(50) of between 0.2 and 12.5 μg ml(-1). The fungus Phaeosphaeria herpotrichoides displayed only leishmanicidal activity with an IC(50) of 0.2 μg ml(-1), which is equivalent to the inhibitory value of amphotericin B. The extract of Microdochium phragmitis displayed specific cytotoxic activity against the UACC-62 cell line with an IC(50) value of 12.5 μg ml(-1). Our results indicate that the unique angiosperms living in Antarctica shelter an interesting bioactive fungal community that is able to produce antiprotozoal and antitumoral molecules. These molecules may be used to develop new leishmanicidal and anticancer drugs.
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